Signal recognition particle 9

Signal recognition particle 9 is a protein that in humans is encoded by the SRP9 gene.

SRP9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E8O, 1E8S, 1RY1, 4UYJ, 4UYK, 5AOX
Identifiers
Aliases	SRP9, ALURBP, signal recognition particle 9kDa, signal recognition particle 9
External IDs	OMIM: 600707; MGI: 1350930; HomoloGene: 37737; GeneCards: SRP9; OMA:SRP9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.12 Start 225,777,813 bp End 225,790,468 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H5 Start 181,952,302 bp End 181,959,972 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone endometrium islet of Langerhans corpus callosum hypothalamus Achilles tendon rectum substantia nigra C1 segment Top expressed in supraoptic nucleus facial motor nucleus primitive streak vestibular sensory epithelium barrel cortex Epithelium of choroid plexus morula neural tube right kidney cumulus cell More reference expression data BioGPS n/a
Gene ontology Molecular function signal recognition particle binding 7S RNA binding protein binding RNA binding Cellular component cytoplasm signal recognition particle receptor complex signal recognition particle cytosol signal recognition particle, endoplasmic reticulum targeting Biological process negative regulation of translational elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane, translocation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6726 27058 Ensembl ENSG00000143742 ENSMUSG00000026511 UniProt P49458 P49962 RefSeq (mRNA) NM_003133 NM_001130440 NM_012058 RefSeq (protein) NP_001123912 NP_003124 NP_001123912.1 NP_036188 Location (UCSC) Chr 1: 225.78 – 225.79 Mb Chr 1: 181.95 – 181.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Rho JH, Qin S, Wang JY, Roehrl MH (July 2008). "Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer". J. Proteome Res. 7 (7): 2959–72. doi:10.1021/pr8000892. PMC 2693877. PMID 18549262.
• Mary C, Scherrer A, Huck L, Lakkaraju AK, Thomas Y, Johnson AE, Strub K (May 2010). "Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein". RNA. 16 (5): 969–79. doi:10.1261/rna.2040410. PMC 2856890. PMID 20348448.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal recognition particle 9 kDa protein