Sjögren syndrome antigen B

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.

SSB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OWX, 1S79, 1S7A, 1YTY, 1ZH5, 2VOD, 2VON, 2VOO, 2VOP
Identifiers
Aliases	SSB, LARP3, La, La/Sjogren syndrome antigen B, small RNA binding exonuclease protection factor La
External IDs	OMIM: 109090; MGI: 98423; HomoloGene: 2366; GeneCards: SSB; OMA:SSB - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q31.1 Start 169,791,933 bp End 169,812,064 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 C2|2 40.95 cM Start 69,691,906 bp End 69,702,190 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii Achilles tendon ventricular zone mucosa of paranasal sinus monocyte epithelium of nasopharynx ganglionic eminence peritoneum left coronary artery anterior pituitary Top expressed in tail of embryo genital tubercle maxillary prominence mandibular prominence ventricular zone embryo embryo abdominal wall supraoptic nucleus ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding nucleic acid binding tRNA binding RNA binding poly(U) RNA binding protein homodimerization activity sequence-specific mRNA binding Cellular component nucleus cytoplasm ribonucleoprotein complex Biological process RNA processing histone mRNA metabolic process protein localization to cytoplasmic stress granule tRNA modification IRES-dependent viral translational initiation tRNA 5'-leader removal tRNA export from nucleus tRNA processing tRNA 3'-end processing nuclear histone mRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6741 20823 Ensembl ENSG00000138385 ENSMUSG00000068882 UniProt P05455 P32067 RefSeq (mRNA) NM_003142 NM_001294145 NM_001110145 NM_009278 NM_001355265 RefSeq (protein) NP_001281074 NP_003133 NP_001103615 NP_033304 NP_001342194 Location (UCSC) Chr 2: 169.79 – 169.81 Mb Chr 2: 69.69 – 69.7 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.

See also

• La domain

Further reading

• Kohsaka H, Yamamoto K, Fujii H, Miura H, Miyasaka N, Nishioka K, Miyamoto T (May 1990). "Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein". The Journal of Clinical Investigation. 85 (5): 1566–74. doi:10.1172/JCI114606. PMC 296607. PMID 1692037.
• Sturgess AD, Peterson MG, McNeilage LJ, Whittingham S, Coppel RL (May 1988). "Characteristics and epitope mapping of a cloned human autoantigen La". Journal of Immunology. 140 (9): 3212–8. doi:10.4049/jimmunol.140.9.3212. PMID 2452201. S2CID 1863804.
• Rauh AJ, Hornig H, Lührmann R (December 1988). "At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach". European Journal of Immunology. 18 (12): 2049–57. doi:10.1002/eji.1830181227. PMID 2464497. S2CID 7014818.
• Chan EK, Sullivan KF, Tan EM (March 1989). "Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding". Nucleic Acids Research. 17 (6): 2233–44. doi:10.1093/nar/17.6.2233. PMC 317593. PMID 2468131.
• Gottlieb E, Steitz JA (March 1989). "Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III". The EMBO Journal. 8 (3): 851–61. doi:10.1002/j.1460-2075.1989.tb03446.x. PMC 400884. PMID 2470590.
• Chambers JC, Kenan D, Martin BJ, Keene JD (December 1988). "Genomic structure and amino acid sequence domains of the human La autoantigen". The Journal of Biological Chemistry. 263 (34): 18043–51. doi:10.1016/S0021-9258(19)81321-2. PMID 3192525.
• Chambers JC, Keene JD (April 1985). "Isolation and analysis of cDNA clones expressing human lupus La antigen". Proceedings of the National Academy of Sciences of the United States of America. 82 (7): 2115–9. Bibcode:1985PNAS...82.2115C. doi:10.1073/pnas.82.7.2115. PMC 397503. PMID 3856888.
• Svitkin YV, Pause A, Sonenberg N (November 1994). "La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA". Journal of Virology. 68 (11): 7001–7. doi:10.1128/jvi.68.11.7001-7007.1994. PMC 237137. PMID 7933082.
• Tröster H, Metzger TE, Semsei I, Schwemmle M, Winterpacht A, Zabel B, Bachmann M (December 1994). "One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome". The Journal of Experimental Medicine. 180 (6): 2059–67. doi:10.1084/jem.180.6.2059. PMC 2191769. PMID 7964483.
• Fan H, Sakulich AL, Goodier JL, Zhang X, Qin J, Maraia RJ (March 1997). "Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes". Cell. 88 (5): 707–15. doi:10.1016/S0092-8674(00)81913-3. PMID 9054510. S2CID 2223069.
• McLaren RS, Caruccio N, Ross J (June 1997). "Human La protein: a stabilizer of histone mRNA". Molecular and Cellular Biology. 17 (6): 3028–36. doi:10.1128/mcb.17.6.3028. PMC 232155. PMID 9154801.
• Grölz D, Bachmann M (April 1997). "The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs". The Biochemical Journal. 323 ( Pt 1) (1): 151–8. doi:10.1042/bj3230151. PMC 1218288. PMID 9173875.
• Helsloot J, Sturgess A (December 1997). "T cell reactivity to Sjögren's syndrome related antigen La(SSB)". The Journal of Rheumatology. 24 (12): 2340–7. PMID 9415639.
• Broekhuis CH, Neubauer G, van der Heijden A, Mann M, Proud CG, van Venrooij WJ, Pruijn GJ (March 2000). "Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution". Biochemistry. 39 (11): 3023–33. doi:10.1021/bi992308c. hdl:2066/187036. PMID 10715123.
• Spångberg K, Wiklund L, Schwartz S (September 2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780.
• Intine RV, Sakulich AL, Koduru SB, Huang Y, Pierstorff E, Goodier JL, Phan L, Maraia RJ (August 2000). "Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366". Molecular Cell. 6 (2): 339–48. doi:10.1016/S1097-2765(00)00034-4. PMID 10983981.
• Nashimoto M, Nashimoto C, Tamura M, Kaspar RL, Ochi K (October 2001). "The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs". Journal of Molecular Biology. 312 (5): 975–84. doi:10.1006/jmbi.2001.5026. PMID 11580243.
• De Nova-Ocampo M, Villegas-Sepúlveda N, del Angel RM (April 2002). "Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA". Virology. 295 (2): 337–47. doi:10.1006/viro.2002.1407. PMID 12033793.
• Intine RV, Dundr M, Misteli T, Maraia RJ (May 2002). "Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs". Molecular Cell. 9 (5): 1113–23. doi:10.1016/S1097-2765(02)00533-6. PMID 12049746.
• Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. hdl:2066/121576. PMID 12096904.