SCO-spondin

SSPOP
Identifiers
Aliases	SSPOP, SCO-spondin, SCO-spondin, pseudogene, SSPO
External IDs	OMIM: 617356; MGI: 2674311; HomoloGene: 45453; GeneCards: SSPOP; OMA:SSPOP - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	149,833,979 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	48,478,184 bp
Gene ontology
Molecular function	peptidase inhibitor activity;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of peptidase activity; cell adhesion; nervous system development; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	23145
	243369
	ENSG00000197558
	ENSMUSG00000029797
	A2VEC9
	Q8CG65
	NM_198455
	NM_173428
	NP_940857
	NP_775604
	Wikidata
View/Edit Human	View/Edit Mouse

SCO-spondin is a protein that in humans is encoded by the SSPO gene.^[5]^[6]^[7] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029797 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5) (5): 1053–61. doi:10.1242/jcs.109.5.1053. PMID 8743952.
^ Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217. S2CID 46625717.
^ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".
^ Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. S2CID 426154.

Meiniel A, Meiniel R, Gonçalves-Mendes N, Creveaux I, Didier R, Dastugue B (2004). "The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines". International Review of Cytology. 230: 1–39. doi:10.1016/S0074-7696(03)30001-4. PMID 14692680.
Meiniel O, Meiniel A (February 2007). "The complex multidomain organization of SCO-spondin protein is highly conserved in mammals". Brain Research Reviews. 53 (2): 321–7. doi:10.1016/j.brainresrev.2006.09.007. PMID 17126404. S2CID 7833761.
Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Gonçalves-Mendes N, Simon-Chazottes D, Creveaux I, Meiniel A, Guénet JL, Meiniel R (July 2003). "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain". Gene. 312: 263–70. doi:10.1016/S0378-1119(03)00622-X. PMID 12909363.
Gonçalves-Mendes N, Blanchon L, Meiniel A, Dastugue B, Sapin V (May 2004). "Placental expression of SCO-spondin during mouse and human development". Gene Expression Patterns. 4 (3): 309–14. doi:10.1016/j.modgep.2003.10.004. PMID 15053980.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197558 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029797 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8743952-5] Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5) (5): 1053–61. doi:10.1242/jcs.109.5.1053. PMID 8743952.

[pmid11008217-6] Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217. S2CID 46625717.

[entrez-7] "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".

[pmid10197783-8] Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. S2CID 426154.

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SCO-spondin

References

Further reading