Saint Eleutherius may refer to:
- Pope Eleutherius (feast day: May 26), 2nd-century pope
- Eleutherius of Rocca d'Arce (feast day: May 29), 12th-century English pilgrim who died at Rocca d'Arce
- Eleutherius of Nicomedia (feast day: October 2), 4th-century soldier who was martyred under Diocletian
- Eleutherius of Auxerre (feast day: August 26), 6th-century bishop of Auxerre
- Eleutherius of Tournai (feast day: February 20) 6th-century bishop of Tournai
- Eleutherius and Antia (feast day: died 121)
- the martyred companion of Saint Denis of Paris (martyred c.250, feast day: October 9)