Saint Genesius may refer to:
- Genesius of Arles, martyred under Maximianus in 303 or 308
- Genesius, Bishop of Clermont (died circa 662), French saint and bishop
- Genesius, Count of Clermont (died 725), noble of Gaul and reputed miracle worker
- Genesius of Lyon (died 679), 37th Archbishop of Lyon
- Genesius of Rome, comedian and patron saint of actors
- Ginés de la Jara, aka Genesius Sciarensis