Santo Tomé (Spanish for Saint Thomas) may refer to the following places:
Argentina
edit- Santo Tomé, Corrientes, a city in the province of Corrientes
- Santo Tomé Department, a department in the province of Corrientes
- Santo Tomé, Santa Fe, a city in the province of Santa Fe
Spain
edit- Santo Tomé, Jaén, a municipality in the province of Jaén, in the autonomous community of Andalusia
- Santo Tomé del Puerto, a municipality in the province of Segovia, in the autonomous community of Castile and León
- Santo Tomé de Zabarcos, a municipality in the province of Ávila, in the autonomous community of Castile and León
Venezuela
edit- Santo Tomé de Guayana de Angostura del Orinoco, the former name of Ciudad Bolívar