São Cristóvão is Portuguese for Saint Christopher. It may also refer to:
- Places in Brazil
- São Cristóvão, Sergipe
- São Cristóvão do Sul, Santa Catarina
- Imperial de São Cristóvão, Rio de Janeiro
- Other
- Paço de São Cristóvão, former imperial palace in Rio de Janeiro
- São Cristóvão de Futebol e Regatas, football club in Rio de Janeiro