SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.[5]

SCG2
Identifiers
AliasesSCG2, CHGC, SN, SgII, secretogranin II
External IDsOMIM: 118930; MGI: 103033; HomoloGene: 2591; GeneCards: SCG2; OMA:SCG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003469

NM_009129
NM_001310680

RefSeq (protein)

NP_003460

NP_001297609
NP_033155

Location (UCSC)Chr 2: 223.6 – 223.6 MbChr 1: 79.41 – 79.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotactic effects on specific cell types, and EM66, whose function is unknown.[6]

See also

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Further reading

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171951Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050711Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gerdes HH, Rosa P, Phillips E, Baeuerle PA, Frank R, Argos P, Huttner WB (July 1989). "The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation". J. Biol. Chem. 264 (20): 12009–15. doi:10.1016/S0021-9258(18)80167-3. PMID 2745426.
  6. ^ "Entrez Gene: SCG2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.