Senotherapeutic's refers to therapeutic agents/strategies that specifically target cellular senescence.[1] Senotherapeutic's include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells [2] and agents that inhibit the pro-inflammatory senescent secretome.[3] Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.[4] Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.
References
edit- ^ Childs et al. (2015). Cellular senescence in aging and age-related disease: from mechanisms to therapy Nature Medicine {{doi:10.1038/nm.4000}}
- ^ Chang J., Wang Y.,Shao L. et al., & Zhou D. (2015). Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine doi:10.1038/nm.4010
- ^ Xu et al. (2015). JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age PNAS {{doi: 10.1073/pnas.1515386112}}
- ^ Burton and Faragher (2015). Cellular senescence: from growth arrest to immunogenic conversion AGE {{doi:10.1007/s11357-015-9764-2}}