Sergey Afanasyev may refer to:
- Sergey Afanasyev (engineer) (1918–2001), Soviet engineer and space and defense industry executive
- Sergey Afanasyev (athlete) (born 1964), Russian middle-distance runner, in 1989 European Athletics Indoor Championships
- Sergey Afanasyev (racing driver) (born 1988), Russian racing driver
This disambiguation page lists articles about people with the same name.
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