Sergio López may refer to:
- Sergio Augusto López Ramírez (born 1961), Mexican politician
- Sergio López (sprinter) (born 1968), Spanish Olympic sprinter
- Sergio López (sprinter, 1999) (born 1999), Spanish sprinter
- Sergio López Miró (born 1968), Spanish swimmer
- Sergio López (footballer, born 1989), Argentine football midfielder for Barcelona SC
- Sergio López (footballer, born 1999), German football right-back for FC Basel