Sidney or Sydney James may refer to:
- Sid James (1913–1976), British-based South African actor and comedian
- Sidney James (footballer) (1891–1917), footballer for Huddersfield Town and Hartlepool United
- Sidney L. James (died 2004), journalist and editor
- Sydney James (priest) (1855–1934), Archdeacon of Dudley
- Syd James (Sydney Victor Austin James, 1895–1966), Australian rules footballer and cricketer
- Syd James (footballer, born 1898) (1898–1969), Australian rules footballer with Geelong
- Sydney Price James (1870–1946), British physician, parasitologist, and malariologist