The siege of Exeter may refer to:
- The Mercian Siege of Exeter (c. 630), also known as the Siege of Caer-Uisc. Almost certainly fictional.
- The Danish Siege of Exeter (893)
- The Siege of Exeter (1068), during the Norman Conquest of England
- The Siege of Exeter (1549) which took place during the Prayer Book Rebellion
- One of the sieges of Exeter that took place during the First English Civil War: