The name Siguenza or Sigüenza (the Spanish original spelling) can refer to:
- The Spanish city Sigüenza and the nearby Paredes de Sigüenza
- A family of Spanish origin, including the following notable individuals:
- Carlos de Sigüenza y Góngora, Mexican colonial officer, author and polymath
- Herbert Siguenza, actor
- Peter C. Siguenza, Guam's former Chief Justice
- Ruben Siguenza, bassist in the band Mink DeVille