George W. Smith House may refer to:
in the United States (by state)
- George W. Smith House (Oak Park, Illinois), listed on the NRHP in Illinois
- George W. Smith House (Elizabethtown, Kentucky), Elizabethtown, Kentucky, listed on the National Register of Historic Places in Hardin County, Kentucky
- George W. Smith Homestead, Mattawamkeag, Maine, listed on the National Register of Historic Places in Penobscot County, Maine
- George W. Smith House (Geneva, Nebraska), Geneva, Nebraska, listed on the National Register of Historic Places in Fillmore County, Nebraska