Metrizoic acid is a pharmaceutical drug that was used as an iodinated contrast medium for X-ray imaging. Its uses included angiography[1] (imaging of blood vessels and heart chambers) and urography[2] (imaging of the urinary tract), but it has been discontinued, at least in the US.[3]
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| ECHA InfoCard | 100.016.147 |
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| Formula | C12H11I3N2O4 |
| Molar mass | 627.943 g·mol−1 |
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It was used in form of its salts, metrizoates. Due to its high osmolality, metrizoic acid had a risk of inducing allergic reactions higher than that of lower osmolar contrast media.[4]
Chemistry
editThe iodine content of metrizoate ranged from 370 mg/ml to 440 mg/ml, with osmolarity has high as 2100 mOsm/kg. The viscosity is 3.4 cP at 37 degree Celsius (human body temperature).[5]
Adverse effects
editSide effects of metrizoate are: urticaria, headache, nausea, vomiting, dizziness, and hypotension. Other side effects include minor electrocardiographic changes such as tachycardia, bradycardia, and inversion of T waves.[6]
References
edit- ^ Vik-Mo H, Danielsen R, Skinningsrud K, Haider T, Bjørkhaug A (1997). "Cardiovascular and electrocardiographic effects of iopentol in left ventricular angiography. Comparison of the low-osmolar, non-ionic iopentol (Imagopaque 350) and the hyper-osmolar, ionic metrizoate meglumine-Na-Ca (Isopaque Coronar 370) in patients with coronary heart disease". European Radiology. 7 (Suppl 4): S156–S161. doi:10.1007/pl00006885. PMID 9204361. S2CID 27742637.
- ^ Zachrisson BE, Jagenburg R (1983). "Comparison of iohexol with metrizoate in urography. A single blind parallel investigation". Acta Radiologica. Supplementum. 366: 30–37. PMID 6147958.
- ^ "Metrizoic acid". DrugBank. Retrieved 3 March 2017.
- ^ "Metrizoic acid - C12H11I3N2O4". PubChem. U.S. National Library of Medicine. Retrieved 3 March 2017.
- ^ Patel R. "Applications in contrast imaging: contrast media basics - important considerations for the pharmacist" (PDF). Braco Diagnostics, Inc. Archived from the original (PDF) on 15 December 2022. Retrieved 15 December 2022.
- ^ Steinberg I, Evans JA (September 1967). "Isopaque 440 (metrizoate); a new cardiovascular contrast medium. Experience with 100 consecutive cases". The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine. 101 (1): 229–233. doi:10.2214/ajr.101.1.229. PMID 4166780.
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