Lei "Stanley" Qi (Chinese: 亓磊; pinyin: Qí Lěi) is an associate professor in the department of bioengineering, and the department of chemical and systems biology at Stanford University. Qi led the development of the first catalytically dead Cas9 lacking endonuclease activity (dCas9), which is the basis for CRISPR interference (CRISPRi). His laboratory subsequently developed CRISPR-Genome Organization (CRISPR-GO).
Lei Stanley Qi | |
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| Born | Qi Lei (亓磊) |
| Nationality | Chinese |
| Alma mater |
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| Known for | CRISPRi, dCas9，CRISPR imaging，CRISPR-GO |
| Awards |
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| Scientific career | |
| Fields | Genome engineering, Synthetic Biology |
| Institutions | Stanford, Chemical and Systems Biology |
| Academic advisors | Adam Arkin, Jennifer Doudna |
| Website | |
Qi is a co-inventor of the University of California patent on the CRISPR gene-editing technology.
Early life and education
editQi obtained his B.S. in physics and math from Tsinghua University,[1] China, Master in physics from UC Berkeley, and PhD in bioengineering from UC Berkeley.[2] During his PhD work at Berkeley, he studied synthetic biology with Adam Arkin, and was the first to explore engineering the CRISPR for targeted gene editing and gene regulation with Jennifer Doudna.[3] After PhD, he performed independent research work as a faculty fellow at UCSF.[4] He joined the Stanford faculty in 2014.[5] [6] [7] [8] [9] [10] [11]
Award
editQi has won awards, including NIH Director's Early Independence Award,[12] Pew Biomedical Scholar,[13] and Alfred. P. Sloan Fellowship.[14]
References
edit- ^ "Tsinghua alumni won the 2017 Sloan Research Award". Tsinghua University News. Retrieved 24 February 2017.
- ^ "BioE Rising Star Seminar". berkeley bioengineering. Retrieved 11 April 2018.
- ^ Greenwood, D.; O'Grady, F. (2016). "Cell scientist to watch – Lei Stanley Qi" (PDF). Cell Science. 129 (3): 303–9. PMC 2041082. PMID 182196.
- ^ "Stanley Lab in UCSF".
- ^ "Stanley Lab in Stanford".
- ^ Qi, LS*; Larson, M. H.; Gilbert, L. A.; Doudna, J. A.; Weissman, J. S.; Arkin, A. P.; Lim, W. A. (2013). "Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression". Cell. 152 (5): 1173–83. doi:10.1016/j.cell.2013.02.022. PMC 3664290. PMID 23452860.
- ^ Gilbert, LA; Larson, MH; Morsut, L; Liu, Z; Brar, GA; Torres, SE; Stern-Ginossar, N; Brandman, O; Whitehead, EH; Doudna, JA; Lim, WA; Weissman, JS; Qi, LS (2013). "CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes". Cell. 154 (2): 442–51. doi:10.1016/j.cell.2013.06.044. PMC 3770145. PMID 23849981.
- ^ Dominguez, AA; Lim, WA; Qi, LS (2016). "Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression". Nat Rev Mol Cell Biol. 17 (1): 5–15. doi:10.1038/nrm.2015.2. PMC 4922510. PMID 26670017.
- ^ Wang, H; Xu, X; Nguyen, CM; Liu, Y; Gao, Y; Lin, X; Daley, TP; Kipniss, NH; La Russa, M; Qi, LS* (2018). "CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization". Cell. S0092-8674 (18): 31185–1. doi:10.1016/j.cell.2018.09.013. PMC 6239909. PMID 30318144.
- ^ Chen, B; Gilbert, LA; Cimini, BA; Schnitzbauer, J; Zhang, W; Li, GW; Park, J; Blackburn, EH; Weissman, JS; Qi, LS; Huang, B (2014). "Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system". Cell. S0092-8674 (18): 31185–1. doi:10.1016/j.cell.2013.12.001. PMC 3918502. PMID 24360272.
- ^ Du, D; Roguev, A; Gordon, DE; Chen, M; Chen, SH; Shales, M; Shen, JP; Ideker, T; Mali, P; Qi, LS; Krogan, NJ (2017). "Genetic interaction mapping in mammalian cells using CRISPR interference". Nat Methods. 14 (6): 577–580. doi:10.1038/nmeth.4286. PMC 5584685. PMID 28481362.
- ^ "NIH Director's Early Independence Award Recipients 2013 Awardees". NIH.
- ^ "Pew Biomedical Scholars". Pew.
- ^ "Sloan Foundation Past Fellows". Sloan Foundation Web.