Sulfafurazole

Sulfafurazole
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601049
Pregnancy; category	To be avoided within two months of term;
Routes of; administration	Oral
ATC code	J01EB05 (WHO) S01AB02 (WHO) QJ01EQ05 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Excretion	Excreted unchanged in urine
Identifiers
	IUPAC name 4-Amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide;
CAS Number	127-69-5 ;
PubChem CID	5344;
DrugBank	DB00263 ;
ChemSpider	5151;
UNII	740T4C525W;
KEGG	D00450 ;
ChEMBL	ChEMBL453 ;
CompTox Dashboard (EPA)	DTXSID6021292 ;
ECHA InfoCard	100.004.418
Chemical and physical data
Formula	C11H13N3O3S
Molar mass	267.30 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	194 °C (381 °F)
	SMILES CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N;
	InChI InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3; Key:NHUHCSRWZMLRLA-UHFFFAOYSA-N;
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Sulfafurazole (INN, also known as sulfisoxazole) is a sulfonamide antibacterial with a dimethyl-isoxazole substituent. It possesses antibiotic activity against a wide range of Gram-negative and Gram-positive organisms.^[1] It is sometimes given in combination with erythromycin (see erythromycin/Sulfafurazole) or phenazopyridine. It is used locally in a 4% solution or ointment.

References

^ Holmes NE, Grauson ML (October 2017). "Sulfonamides". In Paterson DL, McCarthy JS, Mouton JW, Mills J, Grayson ML, Cosgrove SE, Crowe S, Hope W (eds.). Kucers' The Use of Antibiotics (7th ed.). CRC Press. pp. 1571–1624. ISBN 978-1-4987-4796-7.

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