MAP3K7IP3

(Redirected from TAB3)

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.[5][6][7]

TAB3
Identifiers
AliasesTAB3, MAP3K7IP3, NAP1, TGF-beta activated kinase 1/MAP3K7 binding protein 3, TGF-beta activated kinase 1 and MAP3K7 binding protein 3, TGF-beta activated kinase 1 (MAP3K7) binding protein 3
External IDsOMIM: 300480; MGI: 1913974; HomoloGene: 17673; GeneCards: TAB3; OMA:TAB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152787
NM_198312
NM_001399870
NM_001399872
NM_001399873

NM_025729
NM_001358447

RefSeq (protein)

NP_690000

NP_080005
NP_001345376

Location (UCSC)Chr X: 30.83 – 30.98 MbChr X: 85.57 – 85.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[7]

Interactions

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MAP3K7IP3 has been shown to interact with MAP3K7IP2,[5] TAB1[6] and MAP3K7.[5][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157625Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035476Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Nov 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
  6. ^ a b c Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
  7. ^ a b "Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3".

Further reading

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