TFB may refer to:
- "Too Fucking Bad" - Instant message abbreviation
- Trust fund baby - A person who lives off of family wealth
- Toys for Bob - A small video game developer
- Thin-film battery - A type of rechargeable battery
- Archaeal transcription factor B - a protein involved in archaeal transcription.
- The Front Bottoms - indie rock band
- The Future Bites - album by Steven Wilson
This disambiguation page lists articles associated with the title TFB.
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