TKB can refer to:
- The MIPT Terrorism Knowledge Base, commonly abbreviated as TKB.
- Ting Kau Bridge, a cable-stayed bridge in Hong Kong
- TKB, the TasKBuilder program for the RSX-11 computer operating system.
TKB (Tulskoye Konstruktorskoye Byuro / Tula Design Bureau) is the prefix for a series of weapons created by TsKIB SOO: