Tropomodulin 1

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.

TMOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PKG, 4PKH, 4PKI, 4Z8G, 4Z94
Identifiers
Aliases	TMOD1, D9S57E, ETMOD, TMOD, tropomodulin 1
External IDs	OMIM: 190930; MGI: 98775; HomoloGene: 20701; GeneCards: TMOD1; OMA:TMOD1 - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 B1|4 24.49 cM Start 46,038,935 bp End 46,116,032 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle gastric mucosa spinal ganglia left ventricle skeletal muscle tissue body of tongue quadriceps femoris muscle vastus lateralis muscle deltoid muscle trigeminal ganglion Top expressed in quadriceps femoris muscle right ventricle muscle of thigh myocardium of ventricle gastrocnemius muscle temporal muscle utricle skeletal muscle tissue medial head of gastrocnemius muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding actin binding tropomyosin binding Cellular component membrane COP9 signalosome cytoskeleton cytosol cortical cytoskeleton cytoplasm sarcomere myofibril actin filament striated muscle thin filament Biological process adult locomotory behavior lens fiber cell development muscle filament sliding pointed-end actin filament capping muscle contraction actin filament organization myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7111 21916 Ensembl n/a ENSMUSG00000028328 UniProt P28289 P49813 RefSeq (mRNA) NM_003275 NM_001166116 NM_021883 RefSeq (protein) NP_001159588 NP_003266 NP_068683 Location (UCSC) n/a Chr 4: 46.04 – 46.12 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Ursitti JA, Fowler VM (1994). "Immunolocalization of tropomodulin, tropomyosin and actin in spread human erythrocyte skeletons". J. Cell Sci. 107 (6): 1633–9. doi:10.1242/jcs.107.6.1633. PMID 7962203.
• Sung LA, Lin JJ (1994). "Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene". Biochem. Biophys. Res. Commun. 201 (2): 627–34. doi:10.1006/bbrc.1994.1747. PMID 8002995.
• Sussman MA, Bilak M, Kedes L, et al. (1994). "Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions". Exp. Cell Res. 209 (2): 388–91. doi:10.1006/excr.1993.1325. PMID 8262158.
• Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
• Vera C, Sood A, Gao KM, et al. (2000). "Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5". Arch. Biochem. Biophys. 378 (1): 16–24. doi:10.1006/abbi.2000.1802. PMID 10871039.
• McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.
• Chu X, Thompson D, Yee LJ, Sung LA (2001). "Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments". Gene. 256 (1–2): 271–81. doi:10.1016/S0378-1119(00)00327-9. PMID 11054557.
• Greenfield NJ, Fowler VM (2002). "Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin". Biophys. J. 82 (5): 2580–91. Bibcode:2002BpJ....82.2580G. doi:10.1016/S0006-3495(02)75600-2. PMC 1302047. PMID 11964245.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi:10.1016/S0014-5793(03)01438-8. PMID 14741341. S2CID 84342157.
• Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301. S2CID 875146.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vera C, Lao J, Hamelberg D, Sung LA (2006). "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction". Arch. Biochem. Biophys. 444 (2): 130–8. doi:10.1016/j.abb.2005.10.002. PMID 16297372.
• Kong KY, Kedes L (2006). "Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres". J. Biol. Chem. 281 (14): 9589–99. doi:10.1074/jbc.M512064200. PMID 16434395.