Tropomodulin 2

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.

TMOD2
Identifiers
Aliases	TMOD2, N-TMOD, NTMOD, tropomodulin 2
External IDs	OMIM: 602928; MGI: 1355335; HomoloGene: 22817; GeneCards: TMOD2; OMA:TMOD2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 51,751,597 bp End 51,816,363 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 D|9 42.31 cM Start 75,472,903 bp End 75,518,607 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus lateral nuclear group of thalamus primary visual cortex entorhinal cortex pars compacta parietal lobe external globus pallidus postcentral gyrus Top expressed in lateral septal nucleus ventromedial nucleus lateral geniculate nucleus visual cortex anterior amygdaloid area primary visual cortex lateral hypothalamus mammillary body primary motor cortex dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding tropomyosin binding Cellular component cytoplasm growth cone neuron projection cytoskeleton striated muscle thin filament myofibril Biological process pointed-end actin filament capping positive regulation of G protein-coupled receptor signaling pathway neuron-neuron synaptic transmission nervous system development learning or memory muscle contraction actin filament organization myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29767 50876 Ensembl ENSG00000128872 ENSMUSG00000032186 UniProt Q9NZR1 Q9JKK7 RefSeq (mRNA) NM_014548 NM_001142885 NM_001038710 NM_016711 RefSeq (protein) NP_001136357 NP_055363 NP_001033799 NP_057920 Location (UCSC) Chr 15: 51.75 – 51.82 Mb Chr 9: 75.47 – 75.52 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301. S2CID 875146.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Watakabe A, Kobayashi R, Helfman DM (1996). "N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin". J. Cell Sci. 109 (9): 2299–310. doi:10.1242/jcs.109.9.2299. PMID 8886980.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.