Troponin C, skeletal muscle

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.

TNNC2
Identifiers
Aliases	TNNC2, troponin C2, fast skeletal type, CFAP85, FAP85
External IDs	OMIM: 191039; MGI: 98780; HomoloGene: 55727; GeneCards: TNNC2; OMA:TNNC2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 45,823,214 bp End 45,833,745 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 164,619,081 bp End 164,621,887 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis muscle of thigh gastrocnemius muscle thoracic diaphragm quadriceps femoris muscle vastus lateralis muscle Skeletal muscle tissue of biceps brachii body of tongue triceps brachii muscle deltoid muscle Top expressed in intercostal muscle soleus muscle medial head of gastrocnemius muscle masseter muscle tibialis anterior muscle body of femur thoracic diaphragm skeletal muscle tissue muscle of thigh ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding metal ion binding calcium-dependent protein binding actin filament binding calcium ion binding Cellular component cytosol troponin complex Biological process regulation of muscle contraction skeletal muscle contraction muscle filament sliding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7125 21925 Ensembl ENSG00000101470 ENSMUSG00000017300 UniProt P02585 P20801 RefSeq (mRNA) NM_003279 NM_009394 RefSeq (protein) NP_003270 NP_033420 Location (UCSC) Chr 20: 45.82 – 45.83 Mb Chr 2: 164.62 – 164.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Troponin (Tn), is a key protein complex in the regulation of striated muscle contraction, composed of three subunits. The TnI subunit inhibits actomyosin ATPase, the TnT subunit binds tropomyosin and TnC, while the TnC subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin thin filaments. The protein encoded by the TNNC2 gene is the TnC subunit.

Further reading

• Romero-Herrera AE, Castillo O, Lehmann H (1977). "Human skeletal muscle proteins. The primary structure of troponin C.". J. Mol. Evol. 8 (3): 251–70. doi:10.1007/bf01730999. PMID 978749. S2CID 12057790.
• Tomasselli AG, Hui JO, Adams L, et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. doi:10.1016/S0021-9258(18)98721-1. PMID 1907279.
• Gahlmann R, Wade R, Gunning P, Kedes L (1988). "Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts". J. Mol. Biol. 201 (2): 379–91. doi:10.1016/0022-2836(88)90145-3. PMID 3166492.
• Prentice H, Kloner RA, Prigozy T, et al. (1995). "Tissue restricted gene expression assayed by direct DNA injection into cardiac and skeletal muscle". J. Mol. Cell. Cardiol. 26 (10): 1393–401. doi:10.1006/jmcc.1994.1157. PMID 7869399.
• Tiso N, Rampoldi L, Pallavicini A, et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast". Biochem. Biophys. Res. Commun. 230 (2): 347–50. doi:10.1006/bbrc.1996.5958. hdl:11577/2466889. PMID 9016781.
• Townsend PJ, Yacoub MH, Barton PJ (1998). "Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis". Ann. Hum. Genet. 61 (Pt 5): 457–9. doi:10.1046/j.1469-1809.1997.6150457.x. PMID 9459007. S2CID 1450195.
• Vassylyev DG, Takeda S, Wakatsuki S, et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847–52. doi:10.1073/pnas.95.9.4847. PMC 20176. PMID 9560191.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.