TNP1

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.

TNP1
Identifiers
Aliases	TNP1, TP1, transition protein 1
External IDs	OMIM: 190231; MGI: 98784; HomoloGene: 136517; GeneCards: TNP1; OMA:TNP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 216,859,458 bp End 216,860,064 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C3|1 36.94 cM Start 73,054,233 bp End 73,055,068 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis testicle cartilage tissue tail of epididymis cerebellar vermis caput epididymis paraflocculus of cerebellum corpus epididymis Top expressed in seminiferous tubule spermatid perirhinal cortex spermatocyte entorhinal cortex interventricular septum cardiac muscle tissue of left ventricle plantaris muscle extensor digitorum longus muscle choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding Cellular component male germ cell nucleus nucleosome chromosome nucleus Biological process multicellular organism development single strand break repair flagellated sperm motility chromatin remodeling spermatid nucleus differentiation cell differentiation spermatid nucleus elongation nucleosome disassembly negative regulation of transcription, DNA-templated sexual reproduction spermatogenesis spermatid development positive regulation of protein processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7141 21958 Ensembl ENSG00000118245 ENSMUSG00000026182 UniProt P09430 P10856 RefSeq (mRNA) NM_003284 NM_009407 RefSeq (protein) NP_003275 NP_033433 Location (UCSC) Chr 2: 216.86 – 216.86 Mb Chr 1: 73.05 – 73.06 Mb PubMed search
Wikidata
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Further reading

• Meistrich ML, Mohapatra B, Shirley CR, Zhao M (2004). "Roles of transition nuclear proteins in spermiogenesis". Chromosoma. 111 (8): 483–8. doi:10.1007/s00412-002-0227-z. PMID 12743712. S2CID 28866607.
• Chirat F, Martinage A, Briand G, et al. (1991). "Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants" (PDF). Eur. J. Biochem. 198 (1): 13–20. doi:10.1111/j.1432-1033.1991.tb15980.x. PMID 2040274.
• Baskaran R, Rao MR (1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J. Biol. Chem. 265 (34): 21039–47. doi:10.1016/S0021-9258(17)45324-5. PMID 2250010.
• Kleene KC, Borzorgzadeh A, Flynn JF, et al. (1988). "Nucleotide sequence of a cDNA clone encoding mouse transition protein 1". Biochim. Biophys. Acta. 950 (2): 215–20. doi:10.1016/0167-4781(88)90013-9. PMID 3382664.
• Luerssen H, Hoyer-Fender S, Engel W (1988). "The nucleotide sequence of human transition protein 1 cDNA". Nucleic Acids Res. 16 (15): 7723. doi:10.1093/nar/16.15.7723. PMC 338445. PMID 3412903.
• Akama K, Kojima S, Nakano M, et al. (1994). "The amino acid sequence and phosphorylation sites of a boar transition protein 1". Biochem. Mol. Biol. Int. 32 (2): 349–57. PMID 8019440.
• Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
• Yu YE, Zhang Y, Unni E, et al. (2000). "Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4683–8. Bibcode:2000PNAS...97.4683Y. doi:10.1073/pnas.97.9.4683. PMC 18293. PMID 10781074.
• Siffroi JP, Alfonsi MF, Dadoune JP (2001). "Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids". Italian Journal of Anatomy and Embryology = Archivio Italiano di Anatomia ed Embriologia. 103 (4 Suppl 1): 65–74. PMID 11315969.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
• Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.