TRIM15

TRIM15
Identifiers
Aliases	TRIM15, RNF93, ZNF178, ZNFB7, tripartite motif containing 15
External IDs	MGI: 1916347; HomoloGene: 23819; GeneCards: TRIM15; OMA:TRIM15 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,172,693 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	37,178,102 bp
RNA expression pattern
	Top expressed in
	duodenum; ; mucosa of transverse colon; ; rectum; ; right lobe of liver; ; gallbladder; ; human kidney; ; appendix; ; epithelium of colon; ; smooth muscle tissue; ; islet of Langerhans;
	Top expressed in
	intestinal villus; ; ileum; ; jejunum; ; primary oocyte; ; epithelium of small intestine; ; duodenum; ; secondary oocyte; ; zygote; ; yolk sac; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding;
Cellular component	intracellular anatomical structure;
Biological process	mesodermal cell fate determination; positive regulation of DNA-binding transcription factor activity; innate immune response; positive regulation of RIG-I signaling pathway; positive regulation of NF-kappaB transcription factor activity; positive regulation of type I interferon production; negative regulation of intracellular transport of viral material;
	Sources:Amigo / QuickGO
Orthologs
	89870
	69097
ENSG00000235960; ENSG00000227147; ENSG00000233599; ENSG00000204610; ENSG00000224145;
	ENSG00000235905; ENSG00000137384; ENSG00000235259
	ENSMUSG00000050747
	Q9C019
	n/a
	NM_033229; NM_052812
	NM_001024134; NM_001177872
	NP_150232
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[8]

References

^ ^a ^b ^c ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 GRCh38: Ensembl release 89: ENSG00000235960, ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050747 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
^ Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR (Mar 1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection". Am J Hum Genet. 54 (2): 244–51. PMC 1918154. PMID 8304341.
^ Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM (Feb 1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.
^ ^a ^b "Entrez Gene: TRIM15 tripartite motif-containing 15".

Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Harada H, Harada Y, O'Brien DP, et al. (1999). "HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells". Mol. Cell. Biol. 19 (5): 3808–15. doi:10.1128/MCB.19.5.3808. PMC 84222. PMID 10207104.

[refGRCh38Ensembl-1] ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 GRCh38: Ensembl release 89: ENSG00000235960, ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050747 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-5] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[pmid8304341-6] Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR (Mar 1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection". Am J Hum Genet. 54 (2): 244–51. PMC 1918154. PMID 8304341.

[pmid8812418-7] Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM (Feb 1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.

[entrez-8] "Entrez Gene: TRIM15 tripartite motif-containing 15".

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]

TRIM15

References

Further reading