Transcription termination factor, RNA polymerase I

Not to be confused with thyroid transcription factor 1.

Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.

TTF1
Identifiers
Aliases	TTF1, TTF-1, TTF-I, Transcription termination factor, RNA polymerase I, transcription termination factor 1
External IDs	OMIM: 600777; MGI: 105044; HomoloGene: 135863; GeneCards: TTF1; OMA:TTF1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.13 Start 132,375,548 bp End 132,406,851 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 28,950,274 bp End 28,977,668 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell trabecular bone oocyte secondary oocyte pylorus pericardium cardia nipple superior surface of tongue vena cava Top expressed in gastrula neural layer of retina submandibular gland spermatocyte granulocyte Paneth cell thymus ventricular zone morula morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding chromatin binding Cellular component plasma membrane nucleolus nucleoplasm cytosol nucleus Biological process DNA-templated transcription, termination negative regulation of DNA replication regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II cell differentiation termination of RNA polymerase I transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7270 22130 Ensembl ENSG00000125482 ENSMUSG00000026803 UniProt Q15361 Q62187 RefSeq (mRNA) NM_001205296 NM_007344 NM_009442 RefSeq (protein) NP_001192225 NP_031370 NP_033468 Location (UCSC) Chr 9: 132.38 – 132.41 Mb Chr 2: 28.95 – 28.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". EMBO J. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
• Muth V, Nadaud S, Grummt I, Voit R (2001). "Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription". EMBO J. 20 (6): 1353–62. doi:10.1093/emboj/20.6.1353. PMC 145524. PMID 11250901.
• Strohner R, Nemeth A, Jansa P, et al. (2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". EMBO J. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Takano T, Ito Y, Matsuzuka F, et al. (2007). "Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines". Oncol. Rep. 18 (3): 715–20. doi:10.3892/or.18.3.715. PMID 17671725.