TWF2

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.

TWF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VAC, 2W0I
Identifiers
Aliases	TWF2, A6RP, A6r, PTK9L, MSTP011, twinfilin actin binding protein 2
External IDs	OMIM: 607433; MGI: 1346078; HomoloGene: 5272; GeneCards: TWF2; OMA:TWF2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.2 Start 52,228,612 bp End 52,246,788 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 106,080,307 bp End 106,092,588 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh granulocyte gastrocnemius muscle monocyte glutes left ventricle triceps brachii muscle blood mucosa of transverse colon Top expressed in intercostal muscle granulocyte soleus muscle vestibular sensory epithelium interventricular septum thoracic diaphragm medial head of gastrocnemius muscle masseter muscle muscle of thigh digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function actin monomer binding protein binding actin binding phosphatidylinositol-4,5-bisphosphate binding ATP binding protein kinase C binding RNA binding cadherin binding actin filament binding Cellular component cell projection filopodium growth cone intracellular anatomical structure stereocilium perinuclear region of cytoplasm extracellular exosome cytoskeleton lamellipodium cytoplasm myofibril actin filament Biological process cellular response to retinoic acid regulation of actin cytoskeleton organization negative regulation of actin filament polymerization cellular response to growth factor stimulus cell projection organization positive regulation of neuron projection development positive regulation of axon extension positive regulation of lamellipodium assembly regulation of microvillus length sequestering of actin monomers barbed-end actin filament capping regulation of lamellipodium assembly actin filament depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11344 23999 Ensembl ENSG00000247596 ENSMUSG00000023277 UniProt Q6IBS0 Q9Z0P5 RefSeq (mRNA) NM_007284 NM_011876 RefSeq (protein) NP_009215 NP_036006 Location (UCSC) Chr 3: 52.23 – 52.25 Mb Chr 9: 106.08 – 106.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.

Further reading

• Yamada S, Uchimura E, Ueda T, et al. (2007). "Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen". Biochem. Biophys. Res. Commun. 363 (4): 926–30. doi:10.1016/j.bbrc.2007.09.069. PMID 17910947.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.