Talk:5-HT receptor

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Gepiron and ipsapiron are also 5HT1A receptor activators

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I replaced "mirtazepine" for "mirtazapine", which is a more common spelling and has an article under it. - Ktai 08:56, 15 October 2006 (UTC)

Linking to this page

I've seen many pages with references to various 5-HT receptors, particularly in the pharmaceutical and hallucinogenic substance area since that is the area i most frequent, and rarely do i come upon links to this page. In fact i have just discovered this article. I think it'd be appropriate to work on adding this page as a link to the articles in which the references to 5-HT*'s are not linked to anything, so if one might see this i urge you to add the page as a link.--Neur0X ^.talk 04:59, 25 December 2006 (UTC)

or possibly just merge the page

its is quite a large page already so it might be better off separated. If some one was to write separate articles for the sub categories of 5-HT then it could be left alone and linked to as a sub category —The preceding unsigned comment was added by 195.137.90.137 (talk) 14:00, 7 March 2007 (UTC).

LSD as a 5-HT2A agonist AND antagonist?

Hey,

I believe there's been an error. LSD is listed as a 5-HT2A agonist and antagonist, both. This should be impossible, but I'm wary about changing the article without an actual chemist's say on it. (I believe it should be agonist only.) 68.19.27.176 05:16, 16 September 2007 (UTC)

• You are correct as documented here. LSD is a 5-HT2A agonist whose effects can be blocked by 5-HT2A antagonists. I have therefore removed LSD from the 5-HT2A antagonist list. Boghog2 08:02, 16 September 2007 (UTC)

• After more careful reading of the article, LSD is listed as an agonist in the CNS and antagonist in the peripheral nervous system which is possible. There are early reports that LSD acts as antagonist in peripheral tissues [Gaddum JH (1953). "Antagonism between lysergic acid diethylamide and 5-hydroxytryptamine". J. Physiol. (Lond.). 121 (1): 15P. PMID 13085323.], but I cannot find any references specifically mentioning that LSD is a peripheral 5-HT2A antagonist. So I will leave the list as is for now. Boghog2 08:38, 16 September 2007 (UTC)

5-HT5 Receptor

Article lists as Gi-coupled, my sources say it's Gs-coupled. This should be confirmed. Snellios (talk) 10:18, 28 April 2008 (UTC)

Densities?

It would be great to include where different 5HT receptors are most densely located. For example, from the article The interaction between the internal clock and antidepressant efficacy by Racagni: "There is a high density of 5-HT2C receptors within the suprachiasmatic nucleus". —Preceding unsigned comment added by 128.122.113.5 (talk) 17:06, 18 February 2009 (UTC)

Mnemonic

A helpful mnemonic for remembering the coupling may be 5ht-2 Gq, 1 and 5 Gi, all the rest Gs. 3 is G-free. This helps me to remember the coupling, since it is useful information I think it should be added to the page somehow. My previous addition got undone so I figure If its going to be controversal somehow it should go here. I mean the page on the cranial nerves has a bunch of mnemonics, which I found very useful. Ultimately I think adding useful things to the page is more important than an appearance of professionalism, which should come second. And yes it is a mnemonic, the rhyming helps in remembering what would otherwise be an arbitrary set of associations with numbers.Repapetilto (talk) 03:25, 22 September 2009 (UTC)

Personal mnemonics lack the notability guidelines of Wikipedia. You have to provide references that show that a mnemonic is in wide use. Wikipedia as an encyclopedia is not the right place for original research and ideas. You might want to check our sister project Wikiversity. Cacycle (talk) 03:47, 22 September 2009 (UTC)

Well alright, I still think that's misguided though. And I haven't yet used wikiversity but maybe I should begin checking that out.Repapetilto (talk) 03:59, 22 September 2009 (UTC)

Affinities

It would be nice to know the serotonin affinities of the different receptors. Some information from here: Serotonin itself binds at most populations of 5-HT receptors with low nanomolar affinity
Icek (talk) 09:18, 20 August 2010 (UTC)

quetiapine = 5-HT1A agonist or antagonist?

This page lists quetiapine as a 5-HT1A agonist. However, the 5-HT1A page and the Quetiapine page list it as an antagonist for 5-HT1A. Which is correct? Rosemary9999 (talk) 01:13, 29 December 2010 (UTC)Rosemary

it should say that it is a partial agonist at the 5ht1a receptor.

source- Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine’s antidepressant activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33:2303-12.

Assessment comment - from 2007

The comment(s) below were originally left at Talk:5-HT receptor/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

More references needed throughout. -- MarcoTolo 01:27, 6 March 2007 (UTC)

Last edited at 01:27, 6 March 2007 (UTC). Substituted at 06:09, 29 April 2016 (UTC)

Potential article refs

• Drugs Affecting 5-HT Systems
• (review)

Someone sent me these; I think they might be useful to add content from in this article. Seppi333 (Insert 2¢) 00:11, 25 August 2016 (UTC)

References

Long lists have expanded the subtypes table - duplication

Probably the long lists of agonists and antagonists are repeated in the individual 5-HT receptor family articles (eg as in 5-HT6_receptor) so does it add enough value to repeat them here (with the extra cost of maintaining both) ? Similar lists in the Serotonergics template. - Rod57 (talk) 10:57, 30 September 2016 (UTC)

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Table - horizontal listing of column labels

This table is a wonderful resource and, despite its size, should be retained given its completeness, richness of information, and natural place here (the latter leading to ease of discovering/locating).

My main point, though, is to ask whether the column labels listed horizontally across the top of table can be repeated periodically throughout, say, after the listing of each major subclass. Especially for the non-specialist (or those with poor working memory!), it is a chore and highly distracting to have to scroll back up to the top of the table to be reminded what each column is displaying. Gaussgauss (talk) 12:55, 27 October 2018 (UTC)

Hard agree, this table is an excellent resource, but unfortunately in its current state it is unwieldy and you have to be careful not to make false inferences from its content. It could do with an overhaul (as per my comment below) Anditres (talk) 21:53, 9 February 2022 (UTC)

Subtype table is a mess

The subtype table on this page should be excellent and very informative but instead is a misleading mess. If I weren't in such a foul mood I would revamp it myself, but that's not the case, plus I probably should leave it to someone more qualified anyway, so I'll just list the errors or otherwise sloppy/misleading things I have happened to notice here.

In the Function column, I'm not convinced by the capitalisation of the second word in things like Penile Erection, Sexual Behaviour etc.

5-HT1A/agonists: Yohimbine is listed in the selective agonists as an unselective partial agonist. If unselected and nonselected are different, this should be explained or at least have an explanation hinted at, e.g. linking to some relevant article, otherwise it should be moved to nonselective. Ziprasidone should not have Partial agonists capitalised after it in parentheses when it is not capitalised in parentheses elsewhere.

5-HT1A/Uses of drugs that act on this receptor: Grammatically, they've gone for Analgesics (agonists) but Anxiolytics (antagonist). Given that it's not exactly prose, an argument could be made either way, but pluralisation should be consistent.

5-HT1D/Antagonists: It would be nice to know why after Vortioxetine they have given the Ki value: is this because it is particularly potent? Or is it only a partial agonist? I'm asking because I don't know, and this should be indicated in the table like it is for other drugs.

5-HT2A/Agonists: It's unclear why 25I-NMBOe being a full agonist is worthy of mention, the table seems to suggest that partial agonists are indicated between parentheses and the rest are therefore full agonists. Unless it is in some way a super-full agonist? In which case that should be clarified.

5-HT2A/Antagonists: Here we have a list of atypical antipsychotics which is possibly not exhaustive (I would like it to be exhaustive) and below which there are other atypical antipsychotics which have not been included in the list (e.g. Asenapine). For those of us who are still working on having every drug ever memorised, this is confusing and misleading as it suggests that all of the drugs in that cell outside of the list of atypical antipsychotics are not atypical antipsychotics. Furthermore, anywhere in the table where there are many drugs of one type in a cell (being about serotonin receptors we can expect this to happen a lot for antipsychotics (neuroleptics and especially atypicals) and antidepressants) it would be nice to have them chunked as has been done in this cell as it provides a lot of additional information in a relatively short space.

5-HT2C/Function: Addiction should not have a full stop after it.

5-HT2C/Agonists: Here, Trazodone has been described as a hypnotic, but elsewhere it was described as a SARI. I'm not sure if there is a convention regarding drugs that can be classified in multiple ways like this, given that it is indeed both a SARI and a hypnotic, but it should be described in the table in a consistent manner. Personally I would go for calling it a SARI first, but that may be because I'm a psychologist and so preferentially take the classification as a SARI type antidepressant over its ability to induce sleep as its classification, despite actually taking it to induce sleep myself.

5-HT2C/Uses of drugs that act on this receptor: It should be decided whether saying whether it's an agonist or antagonist goes before or after the examples of drugs. I would put it before. In Antipsychotics, the lack of e.g. before Vabicaserin implies that it is the only antipsychotic that acts on this receptor, which is not the case. It also does not even appear in the list of agonists in this row. Furthermore, there are at least 4 antipsychotics indicated in this row to be antagonists, so really this whole thing needs to read as something like: Antipsychotics (agonists, e.g. aripiprazole; antagonists, e.g. clozapine) On top of all of that, the prototypical role of an antipsychotic at this receptor is as an antagonist (aripiprazole is a bit of an oddball among the atypical antipsychotics) so why that is not even mentioned here while their agonism is I do not know.

5-HT3/Antagonists: What is the "several" before antiemetics trying to imply? That unlike other functions listed in this column, there are several of them? (wrong) Or is it that it is only several of them, not all of them, unlike other functions listed in this column? (also wrong)

5-HT3/Uses of drugs that act on this receptor: Antipsychotics should be capitalised. Also, capitalisation of drugs given as examples in this column should be consistent.

5-HT4/Agonists: After Cisapride they have put gastroprokinetic between parentheses but have not afforded the same treatment to Tegaserod, which is later in the row given as the example of a gastroprokinetic.

5-HT6/Uses of drugs that act on this receptor: Antipsychotics get no mention despite the previous cell indicating at least 3 antipsychotics to be antagonists at this receptor. This complaint also replies to the row below and possibly others where I may not have spotted it. The contents of this cell should be put in alphabetical order.

Anditres (talk) 21:46, 9 February 2022 (UTC)

Chromosomes

can we put the subtype classifications table to include chromosomes? It would be interesting to see it at a glance, because of interactions such as 5HT-1 (response to ethanol on 5HTR1B) and those others for ethanol and for my example the alcohol dehydrogenase enzyme on chromosome 4. The inclusion of chromosome positions here would make tracking other receptors and enzymes is what I mean. W;ChangingUsername (talk) 19:57, 16 July 2024 (UTC)