Talk:Butylone
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This paragraph comes from the entry on Bk-MBDB:
"It should be noted that bk-MBDB shares structural similarities to LSD, particularly in the ethylamine side chain and the amine side structure (the double bonded oxygen). In LSD, this side structure was explored by its creator Albert Hofmann because of its structural similarity to nicotinic acid diethylamine. Hofmann was hoping to create an oxytocic drug. It may be possible that by replacing the position of the Nitrogen-Hydrogen bond on the methyl side structure, and replacing it with carbon (thereby creating a diethylamide chain) that this drug will gain significant psychedelic properties."
This information is not chemically nor pharmacologically accurate, and I have removed it from the Bk-MBDB entry. First, the author claims that there is an "ethylamine side chain," which there is not. The ethyl group is once removed from the nitrogen. Furthmore, the author states that the amine "side structure" is a "double bonded oxygen." This is false. That functional group is a ketone. Perhaps the author confused the ketone near the nitrogen as an amide. The next sentence about replacing the "nitrogen-hydrogen bond on the methyl side structure" also does not make sense. If the N-H bond were to be replaced by a methyl group, the molecule would NOT be a "diethylamide," but rather, a dimethylamine. This molecule is NOT an amide, and there is, to the best of my knowldge, no reason to believe that a phenylethylamide (N,N-diethyl or not) should be a psychedelic drug. —The preceding unsigned comment was added by 69.228.197.201 (talk • contribs) 21:51, 13 Jul 2007 (UTC)
While trying to find this drug in The Shulgin Index today, I came across a fact that I felt important to mention. The name "Butylone" was originally the name given to the N-butyl analogue of Methylone, which wouldn't be bk-MBDB, it would actually be bk-MDBU. bk-MDBU, as far as I can tell, has never actually been synthesized, but is listed as an analogue of Methylone in The Shulgin Index, under the name Butylone. There is a side note to this entry, which adds that the name Butylone is used by chemical vendors for the drug bk-MBDB. I felt this was important to mention, as the name is used commonly for the substance in this article but may cause confusion as it was originally the name of a completely different compound. Sbedard88 (talk) 10:33, 15 March 2012 (UTC)
Incorrect structures
editThe structures given in the synthesis section is incorrect. It is a four carbon chain, not five as is currently depicted. 172.78.53.63 (talk) 03:41, 26 June 2018 (UTC)