Talk:Cas12a

Untitled

Hello friends, I will be editing this Wikipedia entry for next few month. — Preceding unsigned comment added by Oscarjuez (talk • contribs) 07:48, 26 February 2016 (UTC)

Hopefully! "Since cells must protect themselves against a host of viruses (to remove viral DNA), it has been hypothesized that each such virus has a complementary endonuclease," indicates some serious misunderstanding or missing proof reading... Yak90 (talk) 00:09, 18 April 2016 (UTC)

This article has the tone of someone who has a vendetta against cas9. — Preceding unsigned comment added by 205.133.149.254 (talk) 21:06, 29 January 2017 (UTC)

I agree with above, some of it sounds like ad-copy. I don't have a particular horse in this race but I'm going to try to note any real/potential challenges with Cpf1 and advantages/disadvantages compared to various site-specific nucleases. Although the more I looked through the research the cooler Cpf1 seems. Krb19 (talk) 22:18, 27 December 2018 (UTC)

Source number four has no link?Tanner Stenlund (talk) 20:42, 28 May 2020 (UTC)

Move

Isn't CRISPR-Cas12 / CRISPR-Cas12a the same as cpf1 ? So isn't a rename in order ? See https://innovativegenomics.org/resources/educational-materials/glossary/cpf1-cas12/ and http://science.sciencemag.org/content/early/2018/02/14/science.aar6245 KVDP (talk) 08:17, 27 March 2018 (UTC)

I think Cas12a should redirect to Cpf1 129.215.47.59 (talk) 11:05, 16 May 2018 (UTC)

I'm pretty sure Cas12a is now the preferred term. Google scholar says that in the past 2 years, 6500 with "cas12a" and 1400 papers with "cpf1", and more with "cas12". I propose changing the article name to "Cas12a (Cpf1)" (and as opposed to current format of "CRISPR/Cpf1" to match the format of "Cas9"). Here is the paper which (I think) first proposed the name change, based on sequence/structure homology (Cas12a/Cpf1 is essentially a Cas9 variant with a significant subunit/domain deletion, hence the small size).

06/19/2021; I believe I wrote the above in ~2019 but failed to sign it -- Krb19

I agree that a name move is useful. I never see cpf1 unlike cas12(a). — Preceding unsigned comment added by Vctrbarbieri (talk • contribs) 12:50, 23 October 2020 (UTC)

I also think the name should be updated to CRISPR/Cas12, but I'm not sure how to edit the page name. All the literature I've seen recently has used Cas12 exclusively (though some mention the old name). AlkalineCoffee (talk) 01:51, 9 March 2021 (UTC)

I have now renamed/moved the page to CRISPR/Cas12a and replaced most of the appearances of Cpf1 --> Cas12a in the body. Thanks everyone for your input. Krb19 (talk) 11:50, 19 July 2021 (UTC)

References

Proposed merge of Cpf1 into CRISPR/Cas12a

Same endonuclease invlolved. Cpf1 article is strict subset of Cas12a article: former talks about bioengineering only, latter talks about that and more. Artoria2e5 🌉 03:40, 10 September 2021 (UTC)

I am going to BOLD it seeing there is a recent discussion. --Artoria2e5 🌉 06:05, 10 September 2021 (UTC)

Requested move 25 February 2022

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion.

The result of the move request was: moved. (closed by non-admin page mover) Vpab15 (talk) 22:46, 6 March 2022 (UTC)

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CRISPR/Cas12a → Cas12a – Avoid subpage of CRISPR, consistent with Cas1 and Cas9. Taylor 49 (talk) 19:59, 25 February 2022 (UTC)

Comment Subpages are not enabled in article space. 🐶 EpicPupper ^{(he/him | talk)} 19:58, 5 March 2022 (UTC)

Comment 2: But it enabled on Article talk pages. Like this one is a subpage of Talk:CRISPR. Not like this alone is good reason to move but still. ---CX Zoom(^he/_him) (^{let's talk}|_contribs) 09:39, 6 March 2022 (UTC)

Support then, the consistency makes it enough to move. 🐶 EpicPupper ^{(he/him | talk)} 16:40, 6 March 2022 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.