Talk:Carbohydrate metabolism

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Eschopp.

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Quality

This article [1] does not comply with encyclopedic and scientific standards and should be rewritten. A good start would be the German article.   Andreas   ^(T) 22:14, 9 September 2006 (UTC)

Clarification from an expert please

"However, animals, including humans, lack the necessary enzymatic machinery and so do not synthesize lipids from carbohydrate."

This statement indicates that humans are unable to produce "adipose fats" from carbohydrates. Would like futher clarification from an expert as much literature indicates otherwise. —Preceding unsigned comment added by 70.239.204.126 (talk) 17:38, 27 August 2008 (UTC)

My understanding here is that lipids are not an allowed substrate for building glucose in animals. Fats are metabolized directly, rather than being converted to glucose. plants can do this, and often store energy in seeds as compact fats and produce glucose as needed from those lipids. In humans, and animals too appatently, glucose can be made from glycogen, if any is available, or from some of the amino acids. Otherwise it comes from food. ww (talk) 19:18, 27 August 2008 (UTC)

Gluconeogenesis is a process in which glucose is formed. The energy necessary comes from fatty acid oxidation, and the required carbon-skeletons come from lactate, glycerol and amino acids. So, no, glucose cannot be synthesized from fatty acids (or 'lipids'); the other way around is however entirely possible within the human cell. Fatty acid synthesis requires acetylCoA, which comes from, among others, glucose-catabolism. So, glucose (or, carbohydrates) delivers carbon (building material) for the synthesis of fatty acids. See Baynes & Dominiczak, Medical Biochemistry.. ++JW (talk) 21:44, 25 October 2008 (UTC)

Symptoms of disorders of carbohydrate metabolism.

Please could someone provide a section on 'Symptoms of disorders of carbohydrate metabolism' in the article? Thank you.81.99.104.50 (talk) 20:12, 3 December 2011 (UTC).

Rate of digestion of simple and complex carbs

Can somebody explain or describe this sentence in the current wikipedia article better? "Simple and complex carbohydrates are digested at similar rates, so the distinction is not very useful for distinguishing nutritional quality." As a reader this sentence is not clear to me. Firstly, I thought that complex carbs were digested at a much slower rate, but apparently not. And secondly, what does the second part of the sentence mean, it's not clear to me. — Preceding unsigned comment added by 88.159.112.181 (talk) 22:39, 12 August 2013 (UTC)

No mention of leptin in Glucoregulation

Someone who can word it better than myself should indicate the link between insulin, blood glucose levels, and leptin. — Preceding unsigned comment added by 76.27.253.131 (talk) 06:07, 10 November 2013 (UTC)

Summary way too verbose and convoluted

This summary is much longer than the actual entry and needs to be distilled down to the basic facts similar to https://en.wikipedia.org/wiki/Protein_metabolism or https://en.wikipedia.org/wiki/Fatty_acid_metabolism . Where does the glucose metabolism take place (in humans) and what is the energy used for should be the majority of the summary. All the stuff about structure should be partitioned out into subgroups in the actual article. Boilingorangejuice (talk) 10:33, 30 November 2015 (UTC)

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Proposed Edits

Lead: condense and add citations

1. Find citation for 1st sentence
2. Simplify 1st paragraph on overall pathway of metabolism
3. Remove: 2nd paragraph on carbohydrate types
4. Remove: 3rd paragraph on complex vs simple carbohydrate effect on blood glucose
5. Relocate: 4th paragraph comparing carbohydrates to fats and proteins as fuel to new section
6. Relocate: 5th paragraph to Glycogenesis
7. Remove: 6th paragraph on carbohydrates--not directly relevant to metabolism
8. Add: Summary of digestion/absorption of carbohydrates that occurs before metabolism
9. Add: Explanation of the variety between different organisms
10. Remove: Catabolism section
11. Within metabolic pathways section, create subsections for each:

• Glycolysis
• Gluconeogenesis
• Glycogenesis
• Glycogenolysis
• Pentose Phosphate Pathway
• Fructose and Galactose Metabolism

Within each subsection, include pathway, energy change, regulation, and related diseases

Best, Eschopp (talk) 07:26, 1 November 2017 (UTC)

No mention of Ketosis

While this article does a great job of detailing the modes of carbohydrate metabolism, it needs a See Also link, if not an entire section, discussing the other major type of metabolism, Ketosis.

The tone of this article implies that carbohydrate metabolism is the standard or major or only metabolic mode, while this is not true at all for the growing number of people who have chosen to change their metabolism to ketosis for the health and athletic benefits it offers.

And not mentioning ketosis is a serious lack when we consider Obesity, a major source of diseases in several countries. Research evidence is mounting that a Ketogenic diet can reverse long-time obesity and manage Type 2 diabetes without the usual continuing increases in medication to counter Insulin resistance.

For these reasons, it would improve this article to add a section comparing glycolysis with ketosis, especially for those people with a propensity for obesity (whether caused by stress, food addiction, genetics, or some other factor). I choose not to add such a section myself, first because I am not a medical expert and second because I dislike seeing my edits reverted. David Spector (talk) 12:26, 1 May 2019 (UTC)