Talk:Dosulepin

Dosulepin vs. dothiepin

Anybody know why dothiepin was renamed to dosulepin? I'm of the impression that dothiepin was the prevalent name, and changing it seems to have caused some amount of confusion. Chris 22:47, 7 July 2006 (UTC)

Its original name was and is dosulepin, it was developed under this trivial name in the former Czechoslovakia back in the 1960's as a derivative of amitriptyline.--Spiperon 22:11, 15 October 2006 (UTC)

Cardiotoxicity

I've heard claims that dothiepin is particularly cardiotoxic at doses not massively higher than what might be prescribed for theraputic use. Anybody know if this is true, and if so, is it worth mentioning in the article? Chris 22:47, 7 July 2006 (UTC)

Well, every anticholinergic TCA is cardiotoxic above the maximal daily dose. As dosulepin is quite anticholinergic (not as much as amitriptyline, but more than desipramine), it is cardiotoxic in higher doses. But not particulary. Amitriptyline, in this respect, is somewhat worse.--Spiperon 22:13, 15 October 2006 (UTC)

Formulae

The formulae does't show the hydrochloride. --Jü (talk) 19:02, 26 August 2009 (UTC)

Pure cis, pure trans or cis,trans-mixture?

Who knows the answer? --Jü (talk) 19:24, 26 August 2009 (UTC)

Mild

"Dosulepin is relatively mild and is used for low-level anxiety, depression and similar disorders"

acording to the data sheetit is as effective as amitriptyline in antireserpine activity, so I'm not sure what exactly it is mild in comparison to?

I'm going to zap this line, as it is unreferenced and I believe, incorrect.

121.209.52.159 (talk) 01:35, 8 April 2010 (UTC) Jonathan

This line has not been deleted... could someone please verify? —Preceding unsigned comment added by 92.234.202.220 (talk) 13:45, 19 March 2011 (UTC)

Structure (image) looks incorrect

... seems to be showing trans-dosulepin, while the CAS apparently does not specify the isomer. Cf the German page for dosulepin. — Preceding unsigned comment added by 50.246.174.181 (talk) 03:51, 18 July 2014 (UTC)

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CAS number

A racemate don't exist with dosulepin - a cis/trans-mixture is NO racemate!--FK1954 (talk) 21:55, 16 March 2020 (UTC)