Talk:NMDA receptor

This article was the subject of a Wiki Education Foundation-supported course assignment, between 10 January 2022 and 27 April 2022. Further details are available on the course page. Student editor(s): Ashleywalterr (article contribs).

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Cpm827. Peer reviewers: Wintertime2029, Blb6175535.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 04:47, 17 January 2022 (UTC)

Gating

I added some detail to the gating of the receptor, since the implication was that the NMDAR was primarily a voltage-gated channel. It is ligand gated, of course, with there being some voltage-dependence of that gating - and the primary apparent voltage-dependence (of the current flow, not the gating) coming from the open-channel block by divalent cations. I wanted to add a reference to the voltage-dependence of gating, but I don't yet know how to edit the reference list. Sorry - I used to edit a lot under a different user name (Synaptidude), but I can't remember the password, and the email account I used is long-dead - so I can't recover it - hence the new user name. Sorry also that I have not done any editing in WP for years, so I don't remember all the protocols for labelling this comment - so sorry if I mess it up. Neuromanncer (talk) 01:22, 2 March 2016 (UTC)

This being the ref I wanted to add: Richard J Clarke and Jon W Johnson J Physiol. 2008 Dec 1; 586(Pt 23): 5727–5741. doi: 10.1113/jphysiol.2008.160622 PMC 2655412 Voltage-dependent gating of NR1/2B NMDA receptors

Neuromanncer (talk) 01:24, 2 March 2016 (UTC)

Untitled

I don't have time to do this now, but someone should change all of the NR1/NR2 to GluN1/GluN2. This is now the preferred denotation that is used in the literature. It keeps the format of the subunit name consistent with other glutamate receptors(for example AMPA subunits are GluA1/2 (which used to be GluR1/2) and Kinate subunits are GluK...) 18 February 2012 — Preceding unsigned comment added by 140.160.61.201 (talk) 20:49, 18 February 2013 (UTC)

I think it could be useful to have a section with examples of cell types that display particular kinds of receptors, both in the NMDA and in the AMPA pages.MNegrello (talk) 07:50, 22 February 2010 (UTC)

There is a nr3a/b subunit for example see: Subunit-specific Roles of Gycine-Binding Domains in Activation of NR1/NR3 "NMDA" Receptors —Preceding unsigned comment added by 141.5.4.128 (talk) 14:13, 16 April 2008 (UTC) Can someone post the list of agonists for NMDA receptors including D-serine, cycloserine and sarcosine. —Preceding unsigned comment added by 76.122.99.157 (talk) 15:05, 13 February 2010 (UTC)

i thougt there was even a n3 subunit...but i cant recall where i read it

The structure section was misleading and out of date. The multimeric NMDA receptor protein contains four subunits, although once it was thought that five subunits were present, as for a muscle nicotinic receptor. However, glutamate receptors are more closely related to potassium channels and share their tetrameric arrangment. These subunits are the products of up to 8 different genes. It is a nice idea to mention structural features of the protein, which is why I added the part about the ligand binding domain. I think that this page needs more updating, and so I will proceed with caution and make a few changes Aplested 13:31, 22 Sep 2004 (UTC)

Most of this article is lifted from the abstract of the Liu and Yang paper in the external link section. Not really well known or quoted, certainly not a patch on the Dingledine review, which has the benefit of being freely available. Aplested 13:51, 22 Sep 2004 (UTC)

Just added a link to the Long-term potentiation thought that it is quite relevant. -- Amelvin 22:40, 13 May 2006 (UTC)

I've been studying receptors and I haven't found any info on wiki about PCP receptors. I read at http://www.esi-topics.com/schizophrenia/interviews/Dr-Daniel-Javitt.html that PCP receptars are a part of NMDA receptors. I think that should be mentioned in this article and searches for PCP receptors should link here. Eddietoran 05:51, 13 October 2006 (UTC)

Although PCP is an NMDA receptor antagonist (PCP makes the receptor unable to activate) it also binds to D₂ dopamine receptors and 5-HT₂ serotonin receptors. Pages that discuss PCP should then link to the pages of these receptors. Sciencepixie 17:36, 14 March 2007 (UTC)

Reference: Molecular Psychiatry 2002, Volume 7, Number 8, Pages 837-844

In the antagonists list, please add Magnesium ion (Mg²⁺)

Methadone is in the 'dual opioids and NMDA antagonists' list, but that is because methadone is a stereomere (sp?), the l-form is an opioid, while d-methadone is an NMDA antagonist. So it's more properly the racemic mixture that is both. — Preceding unsigned comment added by 87.211.115.30 (talk) 14:33, 1 June 2012 (UTC)

We might want to add a section on the functional significance of NMDAR's? E.g. working memory. FlinZ (talk) 13:11, 11 February 2013 (UTC) ——— I suggest that the comment and link to "4-Chlorokynurenine" under the heading of "Some common agents in which weak NMDA receptor antagonism is a secondary or additional action include" is misplaced. It is better put under "Common agents in which NMDA receptor antagonism is the primary mechanism of action". To my knowledge there are not data that suggests that 4-chlorokynurenine has any other mechanism than acting as a very potent and selective glycine-B site antagonist. GC2013 (talk) 18:50, 20 July 2015 (UTC)

I suggest that more about the Ca++ that comes through the NMDA receptor and how it regulates calmodulin-dependent protein kinase II Rincrate (talk) 04:24, 29 September 2015 (UTC)

Untitled

I don't have time to do this now, but someone should change all of the NR1/NR2 to GluN1/GluN2. This is now the preferred denotation that is used in the literature. It keeps the format of the subunit name consistent with other glutamate receptors(for example AMPA subunits are GluA1/2 (which used to be GluR1/2) and Kinate subunits are GluK...) 18 February 2012 — Preceding unsigned comment added by 140.160.61.201 (talk) 20:49, 18 February 2013 (UTC)

I think it could be useful to have a section with examples of cell types that display particular kinds of receptors, both in the NMDA and in the AMPA pages.MNegrello (talk) 07:50, 22 February 2010 (UTC)

There is a nr3a/b subunit for example see: Subunit-specific Roles of Gycine-Binding Domains in Activation of NR1/NR3 "NMDA" Receptors —Preceding unsigned comment added by 141.5.4.128 (talk) 14:13, 16 April 2008 (UTC) Can someone post the list of agonists for NMDA receptors including D-serine, cycloserine and sarcosine. —Preceding unsigned comment added by 76.122.99.157 (talk) 15:05, 13 February 2010 (UTC)

i thougt there was even a n3 subunit...but i cant recall where i read it

The structure section was misleading and out of date. The multimeric NMDA receptor protein contains four subunits, although once it was thought that five subunits were present, as for a muscle nicotinic receptor. However, glutamate receptors are more closely related to potassium channels and share their tetrameric arrangment. These subunits are the products of up to 8 different genes. It is a nice idea to mention structural features of the protein, which is why I added the part about the ligand binding domain. I think that this page needs more updating, and so I will proceed with caution and make a few changes Aplested 13:31, 22 Sep 2004 (UTC)

Most of this article is lifted from the abstract of the Liu and Yang paper in the external link section. Not really well known or quoted, certainly not a patch on the Dingledine review, which has the benefit of being freely available. Aplested 13:51, 22 Sep 2004 (UTC)

Just added a link to the Long-term potentiation thought that it is quite relevant. -- Amelvin 22:40, 13 May 2006 (UTC)

I've been studying receptors and I haven't found any info on wiki about PCP receptors. I read at http://www.esi-topics.com/schizophrenia/interviews/Dr-Daniel-Javitt.html that PCP receptars are a part of NMDA receptors. I think that should be mentioned in this article and searches for PCP receptors should link here. Eddietoran 05:51, 13 October 2006 (UTC)

Although PCP is an NMDA receptor antagonist (PCP makes the receptor unable to activate) it also binds to D₂ dopamine receptors and 5-HT₂ serotonin receptors. Pages that discuss PCP should then link to the pages of these receptors. Sciencepixie 17:36, 14 March 2007 (UTC)

Reference: Molecular Psychiatry 2002, Volume 7, Number 8, Pages 837-844

In the antagonists list, please add Magnesium ion (Mg²⁺)

Methadone is in the 'dual opioids and NMDA antagonists' list, but that is because methadone is a stereomere (sp?), the l-form is an opioid, while d-methadone is an NMDA antagonist. So it's more properly the racemic mixture that is both. — Preceding unsigned comment added by 87.211.115.30 (talk) 14:33, 1 June 2012 (UTC)

We might want to add a section on the functional significance of NMDAR's? E.g. working memory. FlinZ (talk) 13:11, 11 February 2013 (UTC) ——— I suggest that the comment and link to "4-Chlorokynurenine" under the heading of "Some common agents in which weak NMDA receptor antagonism is a secondary or additional action include" is misplaced. It is better put under "Common agents in which NMDA receptor antagonism is the primary mechanism of action". To my knowledge there are not data that suggests that 4-chlorokynurenine has any other mechanism than acting as a very potent and selective glycine-B site antagonist. GC2013 (talk) 18:50, 20 July 2015 (UTC)

I suggest that more about the Ca++ that comes through the NMDA receptor and how it regulates calmodulin-dependent protein kinase II Rincrate (talk) 04:24, 29 September 2015 (UTC)

I would like to see more about the AMPA receptor in reference to the Mg++ ligand that blocks the NMDA receptor until the cell sufficiently depolarizes. Reading this article leaves me wondering why and how the cell depolarizes sufficiently, especially considering that it cannot depolarize through the NMDA receptor due to the Mg++ ligand. Trb9 (talk) 01:58, 27 September 2016 (UTC)

Excitotoxicity

I plan on updating this page with information specific to the role of NMDA receptors to excitotoxicity. Right now I find only a mention of it under the subunit section. I also realize this will have some overlap with the page on excitotoxicity itself. I have gone back and forth on the location of some of this information but since my research has been exclusively on the role of NMDA receptors in toxicity/plasticity I will be uploading it here when I finnish. Any suggestions from those who also have experience in this field will be appreciated. Cpm827 (talk) 04:58, 29 November 2016 (UTC)

External links modified (February 2018)

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Figure 1

A better picture is needed than figure 1. The picture looks like a child's drawing. A digitally created image is required. — Preceding unsigned comment added by 86.129.178.168 (talk) 19:37, 17 August 2018 (UTC)

NMDA & LTP inhibition

Perhaps I am reading the subsection on neural plasticity wrong but it seems to suggest that the opening of NMDA receptors leads to LTD, not LTP?
Purves et al. write in the 5th edition of Neuroscience (p173) that "The NMDA receptor behaves like a molecular coincidence detector: The channel of this receptor opens (to induce LTP) only when two events occur simultaneously: glutamate is bound to the receptor, and the post-synaptic cell is depolarized to relieve the Mg²⁺ block of the channel pore."
Am I reading this section wrong or should I change it? — Preceding unsigned comment added by SK8RBOI (talk • contribs) 03:25, 29 July 2019 (UTC)

poor quality

This article is of poor quality because mostly outdated (e.g. the idea that NMDAR inhibition is supposed to be beneficial has been attributed to different subunit compositions) and should be revised by neuroscientists (please share your knowledge!). — Preceding unsigned comment added by 195.176.238.195 (talk) 14:22, 9 March 2021 (UTC)

Hi. This would be a good review to incorporate: https://www.nature.com/articles/nrn3504. Greetasdf (talk) 12:43, 12 March 2021 (UTC).