Talk:P21

p21 knockouts don't have higher cancer rates?

I have a little bit of an issue with this statement...

despite this, loss-of-function mutations in p21 (unlike p53) do not accumulate in cancer nor do they predispose to cancer incidence. Mice genetically engineered to lack p21 develop normally and are not susceptible to cancer at a higher rate than wild-type mice (unlike p53 knockout mice).

I think there was like 1 study that showed this compared to the hundreds of others that showed just the opposite. Because there is no citation I'm not sure which paper this editor was referring to but if it's this one, the authors found that deletion of p21 prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres. These mice had dysfunctional telomeres. I guess I just want a citation, otherwise I'd think we should go with the bulk of the evidence that suggests that p21 IS very important in tumor suppression.

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^{Niubrad (talk) 22:20, 20 November 2014 (UTC)}

Apoptosis

I would like to add a source regarding p21 and apoptosis but don't know how: Almond, J. B. and G. M. Cohen (2002). "The proteasome: a novel target for cancer chemotherapy." Leukemia 16(4): 433-43. The statement, p21 would'nt under any circumstance lead to apoptosis is not correct as you can read in that paper. --134.2.164.29 (talk) 16:44, 28 February 2010 (UTC)

Thanks a lot, Boghog2! --134.2.167.20 (talk) —Preceding undated comment added 19:18, 28 February 2010 (UTC).

Picture/Structure is misslabeled

The picture of the molecular model shown in the english article is wrong. It does not show p21, but p21 bound to PCNA. This is confirmed when following the link to the original structure. — Preceding unsigned comment added by Taurec81 (talk • contribs) 07:51, 7 September 2018 (UTC)

What is the difference between ras and p21 ?

I am 16 years old and want to understand more amd better. Can anyone explain the difference between ras and p21 ? I am sure it will be useful for others who, like me, want to learn but struggle. Thank you. Maeva11p (talk) 12:52, 5 November 2024 (UTC)