Talk:Platinum nanoparticle

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Platinum nanoparticle

Latest comment: 1 year ago1 comment1 person in discussion

When platinum nanoparticles (PtNPs) suppress propagation of bacteria and disturb viability of cultured cells in some experiments, people think that these hindrances to their survivals are reliable evidences of antibacterial action and cytotoxicity of PtNPs, respectively. However, PtNPs can adsorb oxygen gas as oxygen atoms on their metal surface (Nanoscale Adv 4(21): 4554-4569, 2022), indicating that oxygen deficiency in the experimental system may be the primary cause of inconvenient conditions for aerobic bacteria as well as cultured cells that need oxygen to live. Therefore, the antibacterial action of PtNPs against anaerobes requires higher concentration of platinum in PtNPs than aerobes. Genotoxicity is also often observed in cultured cells treated with PtNPs because hypoxia causes genome instability. If you want to observe real antibacterial effects or cytotoxicity of cells, you have to keep oxygen concentration in experimental systems constant. Finally, I would like to say that experimental results concerning antibacterial action and cytotoxicity of PtNPs reported so far must be interpreted very carefully. Yusei Miyamoto (talk) 04:30, 9 June 2023 (UTC)Reply

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