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editThis is an old drug (1951). I wonder how it was noticed that it delay excretion of therapeutic drugs? Maybe this is some type of purine analogue to help gout sufferers; it helps excrete uric acid. Note that it has some side effects (kidney,liver) but if it hasn't been yanked yet then it's likely got an OK profile. Interestingly, available in China as the ampicillin/probenecid combo, by Chengdu List Pharmaceutical, listpharma.com. If you have expensive ailment it is cheaper to fly to HK or China, buy the medicine OTC, and have a nice holiday on your savings. regford 01:30, 13 September 2006 (UTC) Bold text
72.193.215.135 00:59, 24 September 2007 (UTC) How to make this drug? In stead of using this drug, is there any food has the same effect?
Discussion by 75.162.168.144 moved from article to discussion. "Probenecid's exact mechanism of action in the kidneys' nephrons is unknown. I wish to question this statement. The text Human Physiology by Dee Unglaub Silverthorn explains that gout is caused by elevated levels of uric acid in the plasma, and that the kidney's organic anion transporter (OAT) reclaims uric acid from the urine and returns it to the plasma. If the organic acid probenecid is administered to a patient, the OAT binds to probenecid instead of to uric acid, preventing the reabsorption of uric acid. As a result, more uric acid leaves the body in the urine, lowering the uric acid concentration in the plasma. This is an example of the way in which competition between substrates transported across cell membranes has been put to use in medicine." Can anyone find any more on this? NoQuarter (talk) 00:03, 10 January 2008 (UTC)
How could probenecid be used during World War II if its influence on the penicillin excretion was only discovered in 1950 (year of the first publication)??? I am afraid the source of this data is incorrect.155.105.7.43 (talk) 14:04, 9 February 2010 (UTC)
- Rmv'd "ref" that was actually a footnote, with text: "< ref>This is an obvious anachronism. Influence of probenecid on the excretion of penicillin was not known before 1950 when the first proof was published. </ref >", because, ofc, a ref is not a footnote. And because its uncited, and poorly written, but anyways. If somebody has factual info, they should fix the article. Eaglizard (talk) 17:34, 11 February 2010 (UTC)
OAT vs. URAT
editI think you have the mechanism wrong. http://tmedweb.tulane.edu/pharmwiki/doku.php/probenecid 109.173.173.218 (talk) 13:41, 19 June 2016 (UTC)
Decreasing opiate withdrawal
editWikipedia is not a newspaper Wikipedia:What_Wikipedia_is_not#Wikipedia_is_not_a_newspaper, but a recent study indicates Probenecid may be effective in decreasing opiate withdrawal through a novel mechanism in rodents. This study and novel pharmacological use is unworthy of the main article at this time, but perhaps this information can contribute to the article when appropriate style and additional sources are available.
- nature.com - Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4281.html
- sciencedaily.com - Researchers identify drug that alleviates opioid withdrawal - Existing drug is effective in preventing withdrawal symptoms in opioid-dependent rodents https://www.sciencedaily.com/releases/2017/01/170130110911.htm
- pharmwiki - http://tmedweb.tulane.edu/pharmwiki/doku.php/probenecid
History Section
editThe only thing here is one, admittedly interesting, historical anecdote of specific use. Where is all the critical historical information around the development? Things like: when was it invented, who (company/institution and/or actual researchers) developed it, what was the prompt for the research that lead to its development (i.e. were they trying to make a gout medication, a hyperuricemia medication, a co-drug to reduce excretion of drugs paired with it, some combination there of, or were the developers going for something else all together and these effects were all merely serendipitous?)199.94.1.205 (talk) 15:13, 9 May 2018 (UTC)
New information
editNew study's come out that points to this drug as a possible antiviral. Here's the URL where I caught the story: https://medicalxpress.com/news/2021-09-medicine-gout-covid-.html Here's the study: https://www.nature.com/articles/s41598-021-97658-w
No time/interest to fight the good fight anymore to update articles these days but if someone else wants to take a crack at it and deal with the ankle biters, feel free TMLutas (talk) 19:32, 11 September 2021 (UTC)