Talk:LEKTI

Requested move

The following discussion is an archived discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. No further edits should be made to this section.

The result of the move request was: page moved to LEKTI per discussion. - GTBacchus^(talk) 08:48, 8 July 2011 (UTC)

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SPINK5 → Lympho-epithelial Kazal-type-related inhibitor – Relisted. Jenks24 (talk) 16:00, 22 June 2011 (UTC) SPINK5 refers to the gene encoding for lympho-epithelial Kazal-type-related inhibitor (LEKTI) protein, which does not currently have its own page. Almost all literature note it as LEKTI when referring to the protein itself (simply see the references/further reading articles noted at the bottom of the current page). There's some serious errors with the information on the SPINK5 page currently regardless - I'm more than happy to fix that up but I'm wondering if it would be easier just to create a new page for LEKTI, since this is the most commonly used term to refer to this molecule? I'm not sure whether it would be better to have two separate pages for the gene and protein or to have a single page describing both - if that is the case, I urge the use of LEKTI rather than SPINK5. KingMunch (talk) 08:33, 14 June 2011 (UTC)

Thanks for your note. I agree that this protein is not a enzyme but rather an enzyme inhibitor (my bot made a mistake, sorry). I have corrected the mistake. The scope of this article is meant to cover both the gene and the protein encoded by that gene. Since the subject matter of the gene and the corresponding protein is so interrelated, generally I think it is better not to split these articles into two. The recommended UniProt name for this protein is serine protease inhibitor Kazal-type 5 (see Q9NQ38) and that is why the lead is currently written as it is. However I don't have any objections if you move the page to LEKTI. Cheers. Boghog (talk) 18:21, 22 June 2011 (UTC)

Just to add to the response above, UniProt follow HGNC nomenclature for mammalian genes. In this case HGNC call the gene SPINK5 and LEKTI is listed as a synonym.. --RE73 (talk) 07:22, 23 June 2011 (UTC)

• Question - Are we saying that the page should be called LEKTI or the longer suggested title? Or should it stay where it is now? -GTBacchus^(talk) 18:14, 2 July 2011 (UTC)

SPINK5 is definitely the name for the gene, and fair enough to keep both the gene/protein information in the same article (particularly when it's a stub to start with - although I hope to fix that up when I get a few moments spare). I suggest we call the article LEKTI instead. Sorry for the confusion. KingMunch (talk) 05:30, 3 July 2011 (UTC)

The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page. No further edits should be made to this section.

UniProt names and lead sentence

Just to clarify above, the UniProt naming guidelines state in part:

• preference is given to names that best reflect the common acronym or gene symbol
• a recommended name should not be based on tissue specificity

LEKTI is the common acronym while SPINK5 is the gene symbol. The reason why "serine protease inhibitor Kazal-type 5" was chosen over "lympho-epithelial Kazal-type-related inhibitor" as the recommended UniProt protein name that the former name is not based on tissue specificity while the later is.

Concering the lead sentence in Gene Wiki articles, as discussed here and here, we have tried to make clear that these articles are not only about the human gene/protein, but also orthologs that exist in other species. The wording that was reached through consensus is perhaps a little awkward, but it is both accurate and concise:

• <recommended UniProt name> is a protein that in humans is encoded by the <approved HUGO gene symbol> gene.

The "that" in the above sentence is non-limiting implying that the protein (and gene) exists in other species besides human. Boghog (talk) 01:25, 9 July 2011 (UTC)

thanks for clearing that up - awkward but makes senseKingMunch (talk) 12:44, 9 July 2011 (UTC)