Talk:Tranexamic acid

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Irischen1, Valerievu1, Phongho1. Peer reviewers: SelfieChamps 29.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 11:36, 17 January 2022 (UTC)

A Cheap Drug Is Found to Save Bleeding Victims

http://www.nytimes.com/2012/03/21/health/tranexamic-acid-cheap-drug-is-found-to-staunch-bleeding.html?hp&gwh=340C99F37884CD975EE8ABE6290427C2

This article discusses military use, drug studies, and lack of use outside of the U.K. — Preceding unsigned comment added by 159.121.204.129 (talk) 22:02, 21 March 2012 (UTC)

Edits on 11/02/15 by Irischen1 et al

We improved on the lead by adding more relevant information such as common side effects, precautions, and uses of the drug.

We then added the mechanism of action section.

We improved upon the medical uses category by adding more citations on uses that have been approved.

We also improved the Adverse Effects category by adding percentages and citations. We also added precautions for special populations such as pediatrics, geriatrics, renal/hepatic impairment, and post menopausal women. We also added explanation of the pregnancy category. — Preceding unsigned comment added by Irischen1 (talk • contribs) 00:51, 3 November 2015 (UTC)

Peer Review Suggestions

The draft submission reflects a neutral point of view and used verifiable citations from published material. We offer the following suggestions--for adverse effects: utilize the percentage of adverse effects associated with the drug, and do not include placebo information, include percentages of rare side effects and include hyperlinks for medical terms like pulmonary embolism, DVT, etc and consider adding a contraindication section, for the lead: consider a hyperlink for “World Health Organization's List of Essential Medicines” to wiki page and/or add a sentence explaining what this is, also consider reformatting special populations either w/ bullets or paragraph format. — Preceding unsigned comment added by Sryoung29 (talk • contribs) 05:21, 9 November 2015 (UTC)

Edits on 11/12/15 by Irischen1 et al

• Included the percentage of adverse effects associated with the drug
• Noted that percentages of rare events were determined in post-marketing experience and are not readily available; also inserted a hyperlink for the term post-marketing experience
• Inserted hyperlinks for medical terms like anemia, pulmonary embolism, DVT
• Included a statement about when tranexamic acid should be used with caution
• Inserted a hyperlink for the "World Health Organization's List of Essential Medication"
• Reformatted special populations in a bullet format

Article on use for PPH

https://www.nytimes.com/2017/04/26/health/inexpensive-drug-prevents-deaths-in-new-mothers-study-finds.html TRS-80 (talk) 14:33, 29 April 2017 (UTC)

Cool thanks. Here is the Lancet paper.[1] 20,060 RCT. Decreased risk of death from 1.9% to 1.4% (NNT of 200). Doc James (talk · contribs · email) 18:18, 29 April 2017 (UTC)

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Copyright problem removed

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Error in molecular model?

I think the stick&ball model in the infobox is incorrect. Shouldn't the nitrogen atom on the left have two (not three) hydrogen atoms coming off it? Also (and I might be missing some convention here), shouldn't the oxygen atom on the right with a single bond also have a single hydrogen atom attached, instead of none? — Preceding unsigned comment added by 90.252.31.43 (talk) 09:03, 5 April 2021 (UTC)

This isn't an error, it's due to the fact that tranexamic acid exists as a zwitterion. The skeletal formula ignores this fact but the ball-and-stick model does not because it is based on the crystal structure of the compound, determined experimentally by X-ray diffraction (details here). --Ben (talk) 11:22, 5 April 2021 (UTC)

Thank you!

"Mechanism of Action" is quite technical

I feel the description of the mechanism of action is quite technical, and requires too much background on the pathways involved. It might be helpful to add a statement to the effect that "this medication encourages coagulation, to stop bleeding" (if that is, in fact, the case). OrganicStateMachine (talk) 12:47, 20 November 2022 (UTC)