Taxadien-5alpha-ol O-acetyltransferase

In enzymology, a taxadien-5alpha-ol O-acetyltransferase (EC 2.3.1.162) is an enzyme that catalyzes the chemical reaction

taxadien-5-alpha-ol O-acetyltransferase
Identifiers
EC no.2.3.1.162
CAS no.229032-29-5
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MetaCycmetabolic pathway
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Gene OntologyAmiGO / QuickGO
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acetyl-CoA + taxa-4(20),11-dien-5alpha-ol CoA + taxa-4(20),11-dien-5alpha-yl acetate

Thus, the two substrates of this enzyme are acetyl-CoA and taxa-4(20),11-dien-5alpha-ol, whereas its two products are CoA and taxa-4(20),11-dien-5alpha-yl acetate.

This enzyme participates in diterpenoid biosynthesis.

Nomenclature

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This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase. Other names in common use include acetyl coenzyme A:taxa-4(20),11(12)-dien-5alpha-ol O-acetyl, and transferase.

References

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Further reading

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  • Walker K, Ketchum RE, Hezari M, Gatfield D, Goleniowski M, Barthol A, Croteau R (April 1999). "Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis". Archives of Biochemistry and Biophysics. 364 (2): 273–9. doi:10.1006/abbi.1999.1125. PMID 10190984.