The Mighty Eighth may refer to:
- The Eighth Air Force, a numbered air force (NAF) of the United States Air Force.
- B-17 Flying Fortress: The Mighty 8th, a combat flight simulation videogame published in 2000;
- The Mighty Eighth, an as-yet unreleased film for which a trailer was publicly unveiled in 2014, originally planned to be written by Kurt Johnstad and directed by Rick Jacobson;
- The Mighty Eighth, an abandoned working title for the Apple TV+ series finally titled Masters of the Air, released in January 2024.