Theodora Komnene or Comnena (Greek: Θεοδώρα Κομνηνὴ) may refer to:
- Theodora Komnene (daughter of Alexios I) (born 1096), daughter of Alexios I Komnenos, wife of Constantine Angelos and ancestor of the Angelos dynasty
- Theodora Despina Komnene, daughter of John IV of Trebisond and consort of Aq Qoyunlu's ruler Uzun Hasan
- Theodora Komnene Dalassene, sister of Alexios I Komnenos, wife of Constantine Diogenes II
- Theodora Komnene, Queen of Jerusalem (born c. 1145), niece of Manuel I Komnenos, wife of Baldwin III of Jerusalem
- Theodora Komnene, Duchess of Austria (died 1184), niece of Manuel I Komnenos, wife of Henry II, Duke of Austria
- Theodora Komnene, Princess of Antioch (fl. 1140), niece of Manuel I Komnenos, wife of Bohemond III of Antioch
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