Thomsen–Friedenreich antigen (Galβ1-3GalNAcα1-Ser/Thr) is a disaccharide that serves as a core 1 structure in O-linked glycosylation.[1] First described by Thomsen as a red blood cell's antigen, later research have determined it to be an oncofetal antigen.[2] it is present in the body as a part of membrane transport proteins where it is normally masked from the immune system.[3] It is commonly demasked in cancer cells, with it being expressed in up to 90% of carcinomas, making it a potential target for immunotherapy.[2]
References
edit- ^ Yu, Lu-Gang (2007). "The oncofetal Thomsen–Friedenreich carbohydrate antigen in cancer progression". Glycoconjugate Journal. 24 (8): 411–20. doi:10.1007/s10719-007-9034-3. PMID 17457671. S2CID 9264538.
- ^ a b Kurtenkov, Oleg (2020-03-24). "Profiling of Naturally Occurring Antibodies to the Thomsen-Friedenreich Antigen in Health and Cancer: The Diversity and Clinical Potential". BioMed Research International. 2020: 1–12. doi:10.1155/2020/9747040. ISSN 2314-6133. PMC 7128052. PMID 32280709.
- ^ Karsten, U.; Goletz, S. (July 2015). "What controls the expression of the core-1 (Thomsen—Friedenreich) glycotope on tumor cells?". Biochemistry (Moscow). 80 (7): 801–807. doi:10.1134/S0006297915070019. ISSN 0006-2979. PMID 26541995. S2CID 17278587.
External links
edit- Dippold, W.; Steinborn, A.; Büschenfelde, K. H. M. z. (1990). "The Role of the Thomsen-Friedenreich Antigen As a Tumor-Associated Molecule". Environmental Health Perspectives. 88: 255–7. doi:10.2307/3431086. JSTOR 3431086. PMC 1568008. PMID 2272320.
- King, MJ; Holburn, AM (1979). "Radioassays of blood group M, N and T (Thomsen-Friedenreich) antigens". Immunology. 38 (1): 129–36. PMC 1457886. PMID 511213.
- Singh, R.; Campbell, BJ; Yu, LG; Fernig, DG; Milton, JD; Goodlad, RA; Fitzgerald, AJ; Rhodes, JM (2001). "Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44". Glycobiology. 11 (7): 587–92. doi:10.1093/glycob/11.7.587. PMID 11447138.
- Wolf, Michael F.; Koerner, Ulrike; Schumacher, Kurt (1986). "Specificity of reagents directed to the Thomsen-Friedenreich antigen and their capacity to bind to the surface of human carcinoma cell lines". Cancer Research. 46 (4 Pt 1): 1779–82. PMID 2418954.
- Uhlenbruck, G. (1981). "The Thomsen-Friedenreich (TF) Receptor: An Old History with New Mystery". Immunological Investigations. 10 (3): 251–64. doi:10.3109/08820138109093459. PMID 7037612.
- Dippold, W; Steinborn, A; Meyer; Büschenfelde, KH (August 1990). "The role of the Thomsen-Friedenreich antigen as a tumor-associated molecule". Environ. Health Perspect. 88: 255–7. doi:10.2307/3431086. JSTOR 3431086. PMC 1568008. PMID 2272320.
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