Thug life may refer to:
- Thug Life (group), a hip hop group including Tupac Shakur
- Thug Life, Volume I, the only album released by Thug Life
- Tupac: A Thug Life, a book about Shakur
- "The Hate U Give Little Infants Fucks Everybody", an acronym devised by Shakur
- The Hate U Give, a young adult novel by Angie Thomas
- The Hate U Give (film), a 2018 crime film based on the novel
- "Thug Life", a song from the album Iridescence by Brockhampton
- "Thug Life", a song from the album Issa Album by 21 Savage
- "Thug Life", a song from the album Pray 4 Love by Rod Wave
- Thug Law: Thug Life Outlawz Chapter 1, a compilation album by Big Syke
- Thug Life (2001 film), a 2001 American crime drama film directed by Greg Carter
- Thug Life (2025 film), an upcoming Indian action drama film directed by Mani Ratnam
- Thug life (concept), in gangsta rap music