Trials & Tribulations may refer to:
- Trials & Tribulations (Ace Hood album), 2013
- Trials & Tribulations (Bizzy Bone album), 2007
- Trials & Tribulations (Poetic Hustla'z album), 1997
- Phoenix Wright: Ace Attorney – Trials and Tribulations, 2004, a visual novel adventure video game
- "Trials and Tribulations" (Fargo), a 2023 episode of Fargo