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Ulrich K. Laemmli

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Ulrich K. Laemmli (born 1940), real name Lämmli, is a Professor in the biochemistry and molecular biology departments at University of Geneva. He is known for the refinement of SDS-PAGE, a widely used method for separating proteins based on their electrophoretic mobility.[1] His paper describing the method is among the most cited scholarly journal articles of all time.[2][3][4] His current research involves studying the structural organization of nuclei and chromatin within the cell.[5]

Ulrich K. Laemmli
Born1940 (age 83–84)
Schaffhausen, Switzerland
NationalitySwiss
Known forSDS-PAGE
AwardsLouis-Jeantet Prize for Medicine (1996)
Marcel Benoist Prize (1988)
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Geneva

Career

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Laemmli received a PhD in 1969 at the University of Geneva under Eduard Kellenberger.[6] His thesis was titled "The assembly of the head of bacteriophage T4".[7] He conducted a postdoctoral fellowship at the MRC Laboratory of Molecular Biology under Aaron Klug.[8]

Major scientific contributions

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Although electrophoresis was used to separate proteins before Laemmli's work, he made significant improvements to the method. The term "Laemmli buffer" is often used to describe an SDS-containing buffer that is used to prepare (denature) samples for SDS-PAGE.[1][9]

Awards and honors

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References

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  1. ^ a b Laemmli UK (August 1970). "Cleavage of structural proteins during the assembly of the head of bacteriophage T4". Nature. 227 (5259): 680–685. doi:10.1038/227680a0. PMID 5432063. S2CID 3105149.
  2. ^ "Bio Infobank Library-Kinetics". BioInfoBank Institute. Retrieved 9 January 2010.
  3. ^ Garfield, Eugene (1998). "THE USE OF JOURNAL IMPACT FACTORS AND CITATION ANALYSIS FOR EVALUATION OF SCIENCE". The Scientist. Retrieved 9 January 2010.
  4. ^ Garfield, Eugene (12 February 1990). "The most cited papers of all time" (PDF). Current Comments. 13 (7): 2–14. Retrieved 9 January 2010.
  5. ^ "PROFESSOR ULRICH K. LAEMMLI". Geneva, Switzerland: Département de biologie moléculaire - Université de Genève. 17 October 2008. Retrieved 7 January 2010.
  6. ^ "Prizes". Events, seminars, students' life. University of Geneva Faculties of Medicine and Science. Retrieved 9 November 2023.
  7. ^ Laemmli, U. K.; Quittner, F. (1974). "Maturation of the head of bacteriophage T4: IV. The proteins of the core of the tubular polyheads and in vitro cleavage of the head proteins". Virology. 62 (2): 483–499. doi:10.1016/0042-6822(74)90409-7. PMID 4432376. Retrieved 9 November 2023.
  8. ^ King, Jonathan. "Ulrich Laemmli's development of SDS polyacrylamide gel electrophoresis". MIT Faculty Newsletter. Massachusetts Institute of Technology. Retrieved 9 November 2023.
  9. ^ "SDS-Polyacrylamide Gel Electrophoresis (SDS-PAGE)". Gainesville, FL: EnCor Biotechnology Inc. 2010. Retrieved 9 January 2010.
  10. ^ "The winners of the Louis-Jeantet Prize for medicine". Louis-Jeante Foundation. Retrieved 14 October 2009.
  11. ^ LEMPINEN, EDWARD W. (24 November 2006). "AAAS Members Elected as Fellows" (PDF). Science. 314 (5803). AAAS: 1256–60 [1258]. doi:10.1126/science.314.5803.1256. Retrieved 7 January 2009.
  12. ^ "2006 annual report" (PDF). AAAS. 2006. p. 22. Retrieved 7 January 2010.
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