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Andreas H. Hielscher

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Andreas H. Hielscher
Andreas H. Hielscher
Hielscher in 2018
EducationLeibniz University Hannover
Rice University
Known forOptical tomography, biomedical optics
AwardsFellow, American Institute for Medical and Biological Engineering (2013)
Scientific career
FieldsBiomedical optics, diffuse optical tomography, optical tomography
WorkplacesLos Alamos National Laboratory
SUNY Downstate Medical Center
Columbia University
New York University Tandon School of Engineering
Frank Tittel

Andreas H. Hielscher is a biomedical engineer whose research has focused on biomedical optics, optical tomography, and diffuse optical tomography for medical imaging. He is a professor at the New York University Tandon School of Engineering, where he was appointed founding chair of the Department of Biomedical Engineering in 2020.[1] He directs the Clinical Biophotonics Laboratory, which develops optical imaging methods for clinical applications including cancer, vascular disease, arthritis, and brain imaging.[2] In 2013, he was elected a Fellow of the American Institute for Medical and Biological Engineering for contributions to the design, development, mathematical modeling, and clinical application of optical imaging systems.[3]

Education and early career

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Hielscher studied physics at Leibniz University Hannover, receiving a Diplom in 1991.[4] He then pursued doctoral studies in electrical and computer engineering at Rice University, completing his Ph.D. in 1995 under Frank Tittel, Antonios Mikos, and Nobel Laureate Robert Curl.[4][5] His dissertation was entitled Noninvasive determination of blood oxygenation in the brain by near-infrared reflectance spectroscopy.[6]

After completing his doctorate, Hielscher held a Laboratory President's Postdoctoral Fellowship at Los Alamos National Laboratory, where he continued research on light propagation in biological tissue and optical imaging.[7]

Academic career

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In 1998, Hielscher joined the faculty of SUNY Downstate Medical Center as an assistant professor in the Department of Pathology.[4] In 2001, he joined Columbia University, where he founded and directed the Biophotonics and Optical Radiology Laboratory. At Columbia, he held appointments in biomedical engineering, electrical engineering, and radiology, and served as 2nd chair of the Department of Biomedical Engineering from 2011 to 2012, succeeding Van C. Mow.[8][9]

In 2020, Hielscher was recruited by Dean Jelena Kovačević as the founding chair of the Department of Biomedical Engineering at the New York University Tandon School of Engineering.[1] An article in IEEE Spectrum described the department's emphasis on clinical collaboration and translational biomedical engineering after his move to NYU.[10]

Research

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Hielscher's research has centered on diffuse optical imaging and optical tomography, a biomedical imaging approach that uses near-infrared light to probe tissue structure and physiology. Early in his career, he and collaborators studied radiative-transfer-based models of photon migration in biological tissue and compared transport-theory calculations with diffusion-based approximations.[11] He later co-authored work on optical tomography reconstruction based on the radiative transfer equation.[12]

His laboratory subsequently developed optical tomography systems for dynamic and three-dimensional imaging. These included work on optical tomographic imaging of brain hemodynamics in small animals[13] and dynamic optical tomography for breast cancer imaging.[14]

Clinical applications

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Hielscher and collaborators have applied optical imaging methods to several clinical areas. In breast cancer, his group developed optical imaging approaches intended to monitor hemodynamic response during neoadjuvant chemotherapy.[15][16] A study co-authored by Hielscher reported the use of dynamic optical tomography to evaluate breast cancer response during neoadjuvant chemotherapy.[17]

In vascular imaging, Hielscher's group developed optical tomography approaches for assessing peripheral arterial disease and diabetic vascular complications.[18] Related work used dynamic diffuse optical tomography to image peripheral arterial disease.[19]

His research has also included optical methods for inflammatory joint disease. In collaboration with groups at the Technische Universität Berlin and the University of Göttingen medical school, optical tomographic methods for diagnosing rheumatoid arthritis were developed.[20] Later work by Hielscher, rheumatologist Anca Askanase, and collaborators examined optical imaging for lupus arthritis.[21]

Technology translation

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A startup, CaroRhythm, emerged from research in NYU Tandon’s Clinical Biophotonics Laboratory and focused on a non-invasive wearable system for carotid-artery monitoring in stroke survivors.[22][23]

Honors and professional activities

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Hielscher was elected a Fellow of the American Institute for Medical and Biological Engineering in 2013 for contributions to the design, development, mathematical modeling, and clinical application of optical imaging systems.[3] His other honors and professional activities include the Whitaker Foundation Young Investigator Award, service as general chair of the European Conference on Biomedical Optics, and leadership roles in biomedical engineering and biomedical optics meetings.[4][24]

He has served as an associate editor of IEEE Transactions on Medical Imaging and has participated in review panels and advisory activities for national and international research organizations.[4][25][26]

See also

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References

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  1. 1 2 "Introducing the new chair of Tandon's Department of Biomedical Engineering". NYU Tandon School of Engineering. 8 September 2020. Retrieved 26 August 2026.
  2. ↑ "Andreas H. Hielscher". NYU Tandon School of Engineering. Retrieved 26 August 2026.
  3. 1 2 "Andreas Hielscher, Ph.D." American Institute for Medical and Biological Engineering. Retrieved 26 August 2026.
  4. 1 2 3 4 5 "Andreas Hielscher". NYU NanoBioX. Retrieved 26 August 2026.
  5. ↑ Hielscher, A. H.; Miller, C. E.; Bayard, D. C.; Smolka, K. P.; Curl, R. F.; Tittel, F. K. (1992). "Optimization of a midinfrared high-resolution difference-frequency laser spectrometer". J. Opt. Soc. Am. B. 9 (11): 1962–1967. doi:10.1364/JOSAB.9.001962.
  6. ↑ "Noninvasive determination of blood oxygenation in the brain by near-infrared reflectance spectroscopy". Rice University Research Repository. Retrieved 26 August 2026.
  7. ↑ "Speaker: Andreas Hielscher". GIANT Health and Life Sciences Forum. Retrieved 26 August 2026.
  8. ↑ "Andreas H. Hielscher". Biophotonics and Optical Radiology Laboratory, Columbia University. Retrieved 26 August 2026.
  9. ↑ "Andreas H. Hielscher, PhD". Columbia University Irving Medical Center. Retrieved 26 August 2026.
  10. ↑ Johnson, Dexter (31 October 2022). "NYU Biomedical Engineering Speeds Research from Lab Bench to Bedside". IEEE Spectrum. Retrieved 26 August 2026.
  11. ↑ Hielscher, A. H.; Alcouffe, R. E.; Barbour, R. L. (1998). "Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues". Physics in Medicine and Biology. 43 (5): 1285–1302. doi:10.1088/0031-9155/43/5/017. PMID 9623656.
  12. ↑ Klose, A. D.; Hielscher, A. H. (1999). "Iterative reconstruction scheme for optical tomography based on the equation of radiative transfer". Medical Physics. 26 (8): 1698–1707. doi:10.1118/1.598661. PMID 10501069.
  13. ↑ Bluestone, A.; Stewart, M.; Lei, B.; Kass, I.; Lasker, J.; Abdoulaev, G. S.; Hielscher, A. H. (2004). "Three-dimensional optical tomographic brain imaging in small animals, part I: hypercapnia". Journal of Biomedical Optics. 9 (5): 1046–1062. doi:10.1117/1.1784471. PMID 15447026.
  14. ↑ Flexman, M. L.; Khalil, M. A.; Al Abdi, R.; Kim, H. K.; Fong, C. J.; Desperito, E.; Hershman, D. L.; Barbour, R. L.; Hielscher, A. H. (2011). "Digital optical tomography system for dynamic breast cancer imaging". Journal of Biomedical Optics. 16 (7): 076014. doi:10.1117/1.3599955. PMC 3273311. PMID 21806275.
  15. ↑ "Imaging system helps determine chemo efficacy against breast cancer". UPI. 12 February 2018. Retrieved 26 August 2026.
  16. ↑ "Near-Infrared Light May Identify Breast Cancer Patients Who Will Benefit Most from Chemotherapy". Medical Design Briefs. 3 April 2018. Retrieved 26 August 2026.
  17. ↑ Gunther, Jacqueline E.; Lim, Emerson A.; Kim, Stephen H.; Flexman, Molly L.; Desperito, Erin; Kalinsky, Kevin; Hershman, Dawn L.; Hielscher, Andreas H. (2018). "Dynamic diffuse optical tomography for monitoring neoadjuvant chemotherapy in patients with breast cancer". Radiology. doi:10.1148/radiol.2018161041.
  18. ↑ "Noninvasive Optical Coherence Tomography Could Track Vascular Disease in Diabetics". Diagnostic and Interventional Cardiology. 26 February 2015. Retrieved 26 August 2026.
  19. ↑ Khalil, M. A.; Kim, H. K.; Hielscher, A. H. (2012). "Dynamic diffuse optical tomography imaging of peripheral arterial disease". Biomedical Optics Express. 3 (9): 2288–2298. doi:10.1364/BOE.3.002288. PMC 3447425. PMID 23024936.
  20. ↑ "Laser spürt Gelenkrheuma auf". Die Welt. 9 January 2002. Retrieved 26 August 2026.
  21. ↑ "Experts Describe Strides Made in Understudied Lupus Arthritis". The Rheumatologist. 1 January 2025. Retrieved 26 August 2026.
  22. ↑ "Beyond the Bench: CaroRhythm's Biophotonic Breakthrough for Next-Generation Stroke Detection". NYU Entrepreneurial Institute. 11 February 2026. Retrieved 26 August 2026.
  23. ↑ "Meet the Summer 2026 E-Team Program Cohort". VentureWell. Retrieved 26 August 2026.
  24. ↑ "2025 Northeastern Biomedical Engineering Conference". NEBEC. Retrieved 26 August 2026.
  25. ↑ "Sachverständige 2017" (PDF). Wissenschaftsrat. Retrieved 26 August 2026.
  26. ↑ "Ausschuss Forschungsinfrastrukturen 2025" (PDF). Wissenschaftsrat. Retrieved 26 August 2026.
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