TB11Cs2H1 is a member of the H/ACA-like class of non-coding RNA (ncRNA) molecules that guide the sites of modification of uridines to pseudouridines of substrate RNAs. It is known as a small nucleolar RNA (snoRNA) thus named because of its cellular localization in the nucleolus of the eukaryotic cell. TB11Cs2H1 is a unique H/ACA RNA, it is also known as the splice leader associated RNA (SLA1). It was demonstrated that although this RNA guides pseudouridylation on SL RNA its main function is to properly fold its target in a distinct structure early in its biogenesis.
See also
editReferences
edit- Liang XH, Uliel S, Hury A, et al. (May 2005). "A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification". RNA. 11 (5): 619–645. doi:10.1261/rna.7174805. PMC 1370750. PMID 15840815. Retrieved 2010-09-02.
- Liang XH, Xu YX, Michaeli S (February 2002). "The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA". RNA. 8 (2): 237–246. doi:10.1017/S1355838202018290. PMC 1370245. PMID 11911368. Retrieved 2010-09-02.
- Hury A, Goldshmidt H, Tkacz ID, Michaeli S (January 2009). "Trypanosome spliced-leader-associated RNA (SLA1) localization and implications for spliced-leader RNA biogenesis". Eukaryotic Cell. 8 (1): 56–68. doi:10.1128/EC.00322-08. PMC 2620742. PMID 19028994.
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