Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene .[ 5] [ 6]
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family . Ena-VASP family members contain an N-terminal EVH1 domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions cell membranes. In the mid-region of the protein, family members have a proline -rich region that binds SH3 and WW domain -containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin . VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility . VASP may also be involved in the intracellular signaling pathways that regulate integrin -extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG .[ 6]
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