VPM may refer to:
- Varying Permeability Model
- Ventral posteromedial nucleus, a nucleus of the thalamus; part of the brain.
- Virginia Payload Module, a weapon system planned for Block 5 of the US Navy's Virginia-class submarine
- Volcanic passive margin
- VPM Media Corporation
- VPM SnC, an Italian autogyro company, renamed Magni Gyro in 1996
- Vranken Pommery Monopole
- Vel Phillips Memorial High School, a public high school in Madison, Wisconsin